Longevity — what actually works, by evidence

Approved drug 0

None.

Human trials 0

None.

Human pilots 4

• LongevityUpdated Sep 29EpithalonRussia's longevity peptide, taken in 10-day courses. Its famous 266-person study tested the pineal extract.Evidence · Human pilotsNot legal yet
• LongevityUpdated Sep 29GlutathioneSold as an IV drip at wellness clinics. Its best trial: 54 adults, oral doses, body stores up over 6 months.Evidence · Human pilotsCompounding pharmacy
• LongevityUpdated Sep 29NAD+Clinics sell it by IV because levels halve between 20 and 60. The trials mostly tested pills, not drips.Evidence · Human pilotsCompounding pharmacy
• LongevityUpdated Sep 29SS-31Approved in 2025 for a rare mitochondrial disease. Off-label longevity use rests on Phase 2 data.Evidence · Human pilotsFDA approved

Animal only 11

• LongevityUpdated Sep 29BronchogenLongevity fans take it in capsule cycles for the lungs. Randomized human trials: zero.Evidence · Animal onlyResearch only
• LongevityUpdated Sep 29CardiogenLongevity fans take it in 10–20 day cycles for the heart. Randomized human trials: zero.Evidence · Animal onlyResearch only
• LongevityUpdated Sep 29ChonlutenTaken with Bronchogen in Khavinson cycles for the airways. Randomized human trials: zero.Evidence · Animal onlyResearch only
• LongevityUpdated Sep 29FOXO4-DRISold to longevity buyers as a zombie-cell killer. Human data: none; one 2017 mouse paper started it.Evidence · Animal onlyResearch only
• LongevityUpdated Sep 29HumaninA mitochondrial peptide sold for longevity. Twenty years of cell and rodent work; human trials: zero.Evidence · Animal onlyResearch only
• LongevityUpdated Sep 29KlothoSold as the protein that made mice live longer. Tested on 18 old monkeys' memory; no published human study.Evidence · Animal onlyResearch only
• LongevityUpdated Sep 29MOTS-cSold as exercise in a bottle. Mice ran longer; human trials of injected MOTS-c: zero.Evidence · Animal onlyNot legal yet
• LongevityUpdated Sep 29N-Acetyl-EpithalonEpithalon with chemical caps, sold as longer-lasting. Human studies of the capped version: zero.Evidence · Animal onlyResearch only
• LongevityUpdated Sep 29OvagenTaken for liver and gut support. One lab's research, zero human trials; nothing to do with ovaries.Evidence · Animal onlyResearch only
• LongevityUpdated Sep 29PancragenUsed in Russian clinics alongside diabetes care. The evidence: 20 years of Russian case series.Evidence · Animal onlyResearch only
• LongevityUpdated Sep 29VesugenSold for blood vessels; the identical 3-amino-acid Vesilute is sold for immunity. The evidence is Russian.Evidence · Animal onlyResearch only

No data 0

None.

Also used for longevity 5

Here for a second use. Each meter rates the compound’s main use, the tag on its card.

• Muscle & growth hormoneUpdated Sep 29HGHAnti-aging clinics sell it for body composition. That story began with 12 men in a 1990 study.Evidence · Approved drugFDA approved
• Mind & sleepUpdated Sep 29PinealonUsed in Russia after brain injury and stacked by longevity fans. Its best study: a 72-patient Russian series.Evidence · Human pilotsResearch only
• ImmuneUpdated Sep 29ThymalinA calf-thymus extract used in Russia since 1982. Its famous 266-person aging study came from its developers.Evidence · Human pilotsResearch only
• ImmuneUpdated Sep 29LivagenPitched for liver and immune support in Khavinson cycles. Good randomized human trials: zero.Evidence · Animal onlyResearch only
• ImmuneUpdated Sep 29VilonTwo amino acids, sold for immune support and aging. Independent human trials: zero.Evidence · Animal onlyResearch only