By goal

Fat-Loss Peptides — what actually works, by evidence

Of 14 compounds used for fat loss that aren’t incretin or amylin drugs, 1 is FDA-approved for that use and 3 more have controlled human trials. The other 10 rest on pilot studies or animal data.

The incretin and amylin drugs: GLP-1 & Amylin Shots →

FDA Approved 1

Fat-Loss Peptides · Daily shotSetmelanotideFor rare genetic obesity, not everyday weight loss. Phase 3: 8 of 10 patients lost at least 10% in a year.Evidence · Approved drugFDA approvedChecked Oct 11

Gray Market 13

Fat-Loss Peptides · Daily shotAOD-9604Sold as growth hormone's fat-burning fragment. Its biggest trial, 502 people over 24 weeks, missed its goal.Evidence · Controlled trialsGray marketChecked Oct 11
Fat-Loss Peptides · IV dripBimagrumabPitched as fat loss that keeps muscle. Alone, it took off less weight than semaglutide in a 507-adult trial.Evidence · Controlled trialsGray marketChecked Oct 5
Fat-Loss Peptides · PillTesofensineBack on the gray market since the weight-loss-shot shortages. Phase 2: 9.2% loss in 24 weeks; no Phase 3.Evidence · Controlled trialsGray marketChecked Oct 4
Fat-Loss Peptides · PillCardarineTaken as an exercise pill for fat loss. Its maker quit after 2-year rodent tests found tumors at every dose.Evidence · Human pilotsGray marketTumors in rats and mice at every doseChecked Oct 12
Fat-Loss Peptides · Pill5-Amino-1MQSold as a fat-loss pill for a stubborn metabolism. Every fat-loss result so far: obese mice, from one lab.Evidence · Animal onlyGray marketChecked Oct 11
Fat-Loss Peptides · Daily shotAdipotidePitched as a way to starve fat cells of blood. Obese monkeys lost 11% of their fat; their kidneys objected.Evidence · Animal onlyGray marketKidney injury in monkeysChecked Oct 11
Fat-Loss PeptidesAICARSold as exercise in a pill. The 2008 mice ran 44% farther; no human trial has matched it.Evidence · Animal onlyGray marketChecked Oct 12
Fat-Loss PeptidesBAM15A research chemical that makes mitochondria waste fuel. In mice it stopped fat gain; human trials: zero.Evidence · Animal onlyGray marketChecked Oct 12
Fat-Loss Peptides · PillGW-0742A PPAR-delta agonist pitched as exercise in a pill. The evidence: mouse muscle papers; human trials: zero.Evidence · Animal onlyGray marketChecked Oct 12
Fat-Loss Peptides · Daily shotHGH Fragment 176-191Sold as 'HGH frag' for fat loss. Human trials of this exact fragment: zero; its cousin AOD-9604 failed.Evidence · Animal onlyGray marketChecked Oct 4
Fat-Loss PeptidesNesfatin-1Studied since 2006 as an appetite brake. It has never been given to a person in a trial.Evidence · Animal onlyGray marketChecked Oct 4
Fat-Loss Peptides · PillSLU-PP-332A pill pitched as a workout substitute. The evidence: one 2023 mouse paper where mice ran 70% farther.Evidence · Animal onlyGray marketChecked Oct 12
Fat-Loss Peptides · PillSR9009Sold online as exercise in a pill. The fat loss came from mice injected for 30 days; no human trial.Evidence · Animal onlyGray marketCase report: liver failure, transplantChecked Oct 12

Legal today: 1 FDA approved · 0 Compounded Rx · 13 Gray market
What people actually run: None of the seven named stacks

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