Pair page
HCG with Kisspeptin
Mechanism-tag overlap and published literature for HCG and Kisspeptin, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
glycoprotein-gonadotropinhormonelh-analog
endogenous-hpg-axis-master-regulator
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying HCG and Kisspeptin have published these mechanism-level observations. Not a co-administration recommendation.
Kisspeptin stimulates GnRH release from the hypothalamus, which in turn drives pituitary LH and FSH. Some clinicians use kisspeptin as an alternative or complement to hCG for maintaining HPG axis integrity — working one level higher in the cascade. Research-stage for this indication; not FDA-approved for axis maintenance.
Quick facts
HCG
Kisspeptin
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2014 | HCG | Rastrelli G, Corona G, Mannucci E, Maggi M. Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study. Andrology. 2014;2(6):794-808. PMID: 25099686. (Meta-analysis of spermatogenesis response to gonadotropin replacement — relevant to hCG/FSH… PMID 25099686 | meta-analysis |
| 2018 | HCG | Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, Snyder PJ, Swerdloff RS, Wu FC, Yialamas MA. Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(5):1715-1744. PMID: 29562364. (Soc… PMID 29562364 | human study |
| 2013 | HCG | Hsieh TC, Pastuszak AW, Hwang K, Lipshultz LI. Concomitant intramuscular human chorionic gonadotropin preserves spermatogenesis in men undergoing testosterone replacement therapy. J Urol. 2013;189(2):647-650. PMID: 23260550. PMID 23260550 | human study |
| 2013 | HCG | Kaminetsky J, Werner M, Fontenot G, Wiehle RD. Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel. J Sex Med. 2013;10(6):1628-1635. PMID: 23530575. (Adjacent SERM-based ax… PMID 23530575 | human study |
| 2026 | HCG | WADA. 2026 World Anti-Doping Code Prohibited List. Section S2 — Peptide hormones, growth factors, related substances, and mimetics. World Anti-Doping Agency. (hCG specifically prohibited in males.) | regulatory / registry |
| 2000 | HCG | U.S. Food and Drug Administration. Ovidrel (choriogonadotropin alfa) Prescribing Information. EMD Serono. First approved 2000. | regulatory / registry |
| — | HCG | U.S. Food and Drug Administration. Pregnyl (chorionic gonadotropin) Prescribing Information. Organon USA Inc. | regulatory / registry |
| — | HCG | U.S. Food and Drug Administration. Novarel (chorionic gonadotropin) Prescribing Information. Ferring Pharmaceuticals. | regulatory / registry |
| 2018 | HCG | Lee JA, Ramasamy R. Indications for the use of human chorionic gonadotropic hormone for the management of infertility in hypogonadal men. Transl Androl Urol. 2018;7(Suppl 3):S348-S352. PMID: 30050800. PMID 30050800 | research article |
| 2017 | HCG | Shiraishi K, Matsuyama H. Gonadotoropin actions on spermatogenesis and hormonal therapies for spermatogenic disorders. Endocr J. 2017;64(2):123-131. PMID: 28100858. PMID 28100858 | research article |
| 2015 | HCG | Ramasamy R, Armstrong JM, Lipshultz LI. Preserving fertility in the hypogonadal patient: an update. Asian J Androl. 2015;17(2):197-200. PMID: 25652635. PMID 25652635 | research article |
| 2013 | HCG | Crosnoe LE, Grober E, Ohl D, Kim ED. Exogenous testosterone: a preventable cause of male infertility. Transl Androl Urol. 2013;2(2):106-113. PMID: 26813847. (Mechanism and clinical framing of TRT-induced infertility and hCG-based prevention.) PMID 26813847 | research article |
| 2022 | Kisspeptin | Thurston L, Hunjan T, Ertl N, Wall MB, Mills EG, Suladze S, et al. Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Netw Open. 2022;5(10):e2236131. PMID: 36227594. PMID 36227594 | human trial |
| 2018 | Kisspeptin | Trevisan CM, Montagna E, de Oliveira R, Christofolini DM, Barbosa CP, Crandall KA, Bianco B. Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction? Cell Physiol Biochem. 2018;49(4):1259-1276. PMID: 30205368. PMID 30205368 | human study |
| 2017 | Kisspeptin | Comninos AN, Wall MB, Demetriou L, Shah AJ, Clarke SA, Narayanaswamy S, et al. Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest. 2017;127(2):709-719. PMID: 28112678. PMID 28112678 | human study |
| 2014 | Kisspeptin | Skorupskaite K, George JT, Anderson RA. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014;20(4):485-500. PMID: 24615662. PMID 24615662 | human study |
| 2011 | Kisspeptin | Chan YM, Butler JP, Pinnell NE, Pralong FP, Crowley WF Jr, Ren C, et al. Kisspeptin resets the hypothalamic GnRH clock in men. J Clin Endocrinol Metab. 2011;96(6):E908-915. PMID: 21470993. PMID 21470993 | human study |
| 2009 | Kisspeptin | Jayasena CN, Nijher GM, Chaudhri OB, Murphy KG, Ranger A, Lim A, et al. Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. J Clin Endocrinol Metab. 2009;94(11):… PMID 19820030 | human study |
| 2005 | Kisspeptin | Dhillo WS, Chaudhri OB, Patterson M, Thompson EL, Murphy KG, Badman MK, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005;90(12):6609-6615. PMID: 16174713. PMID 16174713 | human study |
| 2007 | Kisspeptin | Lapatto R, Pallais JC, Zhang D, Chan YM, Mahan A, Cerrato F, et al. Kiss1−/− mice exhibit more variable hypogonadism than Gpr54−/− mice. Endocrinology. 2007;148(10):4927-4936. PMID: 17595229. PMID 17595229 | preclinical, in vivo |
| 2015 | Kisspeptin | Abbara A, Jayasena CN, Christopoulos G, Narayanaswamy S, Izzi-Engbeaya C, Nijher GM, et al. Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy. J Clin Endocrinol Met… PMID 26192876 | preclinical, in vitro |
| 2014 | Kisspeptin | Jayasena CN, Abbara A, Comninos AN, Nijher GM, Christopoulos G, Narayanaswamy S, et al. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. J Clin Invest. 2014;124(8):3667-3677. PMID: 25036713. PMID 25036713 | preclinical, in vitro |
| 2020 | Kisspeptin | Abbara A, Eng PC, Phylactou M, Clarke SA, Hunjan T, Roberts R, et al. Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders. J Clin Invest. 2020;130(12):6739-6753. PMID: 33196464. PMID 33196464 | research article |
| 2015 | Kisspeptin | Clarke H, Dhillo WS, Jayasena CN. Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders. Endocrinol Metab (Seoul). 2015;30(2):124-141. PMID: 26194072. PMID 26194072 | research article |
Related pair pages
More research context
Frequently asked
Have HCG and Kisspeptin been studied together?
Researchers have published mechanistic-level co-administration discussion of HCG and Kisspeptin. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do HCG and Kisspeptin share?
HCG and Kisspeptin do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of HCG and Kisspeptin?
HCG: Approved (hypogonadism, cryptorchidism, infertility). Kisspeptin: Not approved; active Phase 2. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on HCG and Kisspeptin?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the HCG profile and the Kisspeptin profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026