Pair page
GHRP-2 with GHRP-6
Mechanism-tag overlap and published literature for GHRP-2 and GHRP-6, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
GHRP-2 unique
none
Shared
ghrelin-receptor-agonistgrowth-hormone-secretagogue
GHRP-6 unique
none
Quick facts
GHRP-2
RouteSubQ / IV / IM / Intranasal
Half-life~15–60 min
FDA statusInvestigational (Category 2 bulk)
WADABanned (S2)
GHRP-6
RouteSubQ / IV / IM / Intranasal
Half-life~15–60 min
FDA statusInvestigational (Category 2 bulk)
WADABanned (S2)
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2001 | GHRP-2 | Arvat E, Maccario M, Di Vito L, et al. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab. 2001;86(3):1169-1174. PMID: 1… PMID 11238504 | human study |
| 2005 | GHRP-2 | Granado M, Priego T, Martín AI, Villanúa MA, López-Calderón A. Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. Am J Physiol Endocrinol Metab. 2005;288(3):E486-E492. PMID: 15507534. PMID 15507534 | preclinical, in vivo |
| 2004 | GHRP-2 | Doi N, Furukawa M, Sato C, Sasaki M, et al. Pharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide. Arzneimittelforschung. 2004;54(12):857-867. PMID: 15646370. (Foundational pharmacology characterization by Kaken.) PMID 15646370 | mechanism / discovery |
| 1999 | GHRP-2 | Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-660. PMID: 10604470. (Ghrelin discovery — endogenous ligand.) PMID 10604470 | mechanism / discovery |
| 1996 | GHRP-2 | Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273(5277):974-977. PMID: 8688086. (GHS-R1a cloning.) PMID 8688086 | mechanism / discovery |
| 2017 | GHRP-2 | Berlanga-Acosta J, et al. Synthetic Growth Hormone-Releasing Peptides (GHRPs): A Historical Appraisal of the Evidences Supporting Their Cytoprotective Effects. Medicc Rev. 2017. PMC5392015. (Class review of cytoprotective evidence.) | review |
| 2026 | GHRP-2 | WADA Prohibited List 2026. World Anti-Doping Agency. wada-ama.org. (GHRP family banned under S2.) | regulatory / registry |
| 2025 | GHRP-2 | FDA. Bulk Drug Substances That Raise Significant Safety Risks (Category 2) Under Section 503A / 503B. FDA.gov. Updated 2025-2026. | regulatory / registry |
| — | GHRP-2 | Thomas A, Höppner S, Geyer H, et al. Determination of growth hormone-releasing peptides in serum by LC-MS/MS for sports drug testing. (WADA detection methodology applicable to GHRP-2.) | regulatory / registry |
| 2004 | GHRP-2 | Furuta S, Shimada O, Doi N, Ukai K, Nakagawa T, Watanabe J, Imaizumi M. General pharmacology of KP-102 (GHRP-2), a potent growth hormone-releasing peptide. Arzneimittelforschung. 2004;54(12):868-880. PMID: 15646371. (Safety pharmacology evaluation.) PMID 15646371 | research article |
| 2004 | GHRP-2 | Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP 102, WAY GPA 748. Drugs R D. 2004;5(4):236-239. PMID: 15230633. (Drug development profile.) PMID 15230633 | research article |
| 2001 | GHRP-2 | Bowers CY. Unnatural growth hormone-releasing peptide begets natural ghrelin. J Clin Endocrinol Metab. 2001;86(4):1464-1469. PMID: 11297568. PMID 11297568 | research article |
| 2013 | GHRP-6 | Cabrales A, Gil J, Fernández E, Valenzuela C, Hernández F, García I, Hernández A, Besada V, Reyes O, Padrón G, Berlanga J, Guillén G, González LJ. Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers. Eur J Pharm Sci. 2013;48(1-2):… PMID 23159700 | human study |
| 2001 | GHRP-6 | Hataya Y, Akamizu T, Takaya K, et al. A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans. J Clin Endocrinol Metab. 2001;86(9):4552. PMID: 11549709. PMID 11549709 | human study |
| 2013 | GHRP-6 | Cabrales A, Berlanga J, et al. Cardiotropic effect of GHRP-6: in vivo characterization by echocardiography. Biotecnología Aplicada. 2013;30(4):285-289. (Inotropic effect characterization.) | preclinical, in vivo |
| 2005 | GHRP-6 | Depoortere I, De Winter B, Thijs T, De Man J, Pelckmans P, Peeters T. Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. Eur J Pharmacol. 2005;515(1-3):160-168. PMID: 15890335. (Gastric prokinetic mechanism.) PMID 15890335 | preclinical, in vivo |
| 1984 | GHRP-6 | Bowers CY, Momany FA, Reynolds GA, Hong A. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 1984;114(5):1537-1545. PMID: 6142782. (Foundational GHRP-6 discovery paper.) PMID 6142782 | preclinical, in vivo |
| 2002 | GHRP-6 | Bodart V, Febbraio M, Demers A, McNicoll N, Pohankova P, Perreault A, Sejlitz T, Escher E, Silverstein RL, Lamontagne D, Ong H. CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. Circ Res. 2002;90(8):844-849. PMID: 11988484. (CD36 cardiopr… PMID 11988484 | mechanism / discovery |
| 2026 | GHRP-6 | WADA Prohibited List 2026. World Anti-Doping Agency. wada-ama.org. (GHRP family banned under S2.) | regulatory / registry |
| 2025 | GHRP-6 | FDA. Bulk Drug Substances That Raise Significant Safety Risks (Category 2) Under Section 503A / 503B. FDA.gov. Updated 2025-2026. | regulatory / registry |
| 2024 | GHRP-6 | Berlanga-Acosta J, Cibrian D, Valiente-Mustelier J, Suárez-Alba J, García-Ojalvo A, Falcón-Cama V, Jiang B, Wang L, Guillén-Nieto G. Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechani… PMID 38873418 | research article |
| 2007 | GHRP-6 | Berlanga J, Cibrian D, Guevara L, Dominguez H, Alba JS, Seralena A, et al. Growth-hormone-releasing peptide 6 (GHRP-6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction. Clin Sci (Lond). 2007;112(4):241-250. PMID: 17034365. (… PMID 17034365 | research article |
| 1991 | GHRP-6 | Bowers CY, Sartor AO, Reynolds GA, Badger TM. On the actions of the growth hormone-releasing hexapeptide, GHRP. Endocrinology. 1991;128(4):2027-2035. PMID: 2004616. PMID 2004616 | research article |
Related pair pages
More research context
Frequently asked
Have GHRP-2 and GHRP-6 been studied together?
No co-administration studies between GHRP-2 and GHRP-6 are catalogued on Kalios. The pair page lists only the individual published literature for each compound and any shared mechanism tags.
What mechanisms do GHRP-2 and GHRP-6 share?
GHRP-2 and GHRP-6 share these mechanism tags on their Kalios profiles: ghrelin-receptor-agonist, growth-hormone-secretagogue. Tags are descriptive and verbatim from each compound profile — not an inference of combined effect.
What is the FDA status of GHRP-2 and GHRP-6?
GHRP-2: Investigational (Category 2 bulk). GHRP-6: Investigational (Category 2 bulk). FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on GHRP-2 and GHRP-6?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the GHRP-2 profile and the GHRP-6 profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026