Enclomiphene Citrate with Zuclomiphene

The receipt

Evidence on the combination

Approved drug

Helo et al., 2017 · Young et al., 1999

What each does alone

• Libido & hormones · PillEnclomiphene CitrateSERMMen's clinics prescribe it to raise testosterone and keep fertility. The FDA turned it down in 2015.Controlled trialsCompounded RxChecked Oct 23
• Libido & hormones · PillZuclomipheneSERMClomiphene's other half, tested for hot flashes. Its only Phase 2 result is an unpublished interim readout.Animal onlyGray marketChecked Oct 23

Mechanism overlap · reasoning, not evidence

Enclomiphene Citrate

Small Molecule — Selective Estrogen Receptor Modulator (SERM)

Zuclomiphene

Small Molecule — SERM (Selective Estrogen Receptor Modulator)

Shared mechanism tag

selective estrogen receptor modulator

Reasoning, not evidence: what each is described to do says nothing about what they do together.

What the studies found

Men on long-term clomiphene (Helo et al., 2017)

• What was given — 15 men with secondary hypogonadism on clomiphene citrate 25 mg a day (median 25.9 months).
• What it found — Median total testosterone rose from 205 to 488 ng/dL. Median enclomiphene was 2.2 ng/mL and zuclomiphene 44.0 ng/mL, a 20:1 ratio in zuclomiphene's favour.
• Limits — 15 men, one blood sample each.

Women on clomiphene for ovulation (Young et al., 1999)

• What was given — 14 anovulatory infertile women, three to six cycles of clomiphene citrate 50 to 150 mg on cycle days 5 to 9.
• What it found — Zuclomiphene built up across consecutive cycles, then plateaued; enclomiphene was undetectable on cycle day 3.

The Clomiphene page covers the drug itself.