Pair page
Enclomiphene Citrate with Gonadorelin
Mechanism-tag overlap and published literature for Enclomiphene Citrate and Gonadorelin, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
selective-estrogen-receptor-modulatorserm
gnrhsynthetic-gonadotropin-releasing-hormone
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Enclomiphene Citrate and Gonadorelin have published these mechanism-level observations. Not a co-administration recommendation.
Selective estrogen receptor modulator that blocks estrogen feedback at the hypothalamus and pituitary, potentially amplifying pituitary responsiveness to gonadorelin. Some advanced TRT protocols combine both for stronger LH / FSH preservation, though this combination has limited formal study and adds complexity.
Quick facts
Enclomiphene Citrate
Gonadorelin
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2016 | Enclomiphene Citrate | Kim ED, McCullough A, Kaminetsky J. Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement. BJU Int. 2016;117(4):677-685. PMID: 26496621. (Pivotal Phase 3 RCT data.) PMID 26496621 | human trial, Phase 3 |
| — | Enclomiphene Citrate | ClinicalTrials.gov NCT01406964, NCT01403038 — Repros Phase 3 ZA-203 / ZA-204 trials. | human trial, Phase 3 |
| 2015 | Enclomiphene Citrate | Helo S, Ellen J, Mechlin C, Feustel P, Grossman M, Ditkoff E, McCullough A. A randomized prospective double-blind comparison trial of clomiphene citrate and anastrozole in raising testosterone in hypogonadal infertile men. J Sex Med. 2015;12(8):1761-1769. | human trial |
| 2019 | Enclomiphene Citrate | Earl JA, Kim ED. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism. Expert Rev Endocrinol Metab. 2019;14(3):157-165. (Modern clinical review.) | human study |
| 2018 | Enclomiphene Citrate | Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, Snyder PJ, Swerdloff RS, Wu FC, Yialamas MA. Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(5):1715-1744. | human study |
| 2016 | Enclomiphene Citrate | Pastuszak AW, Wiehle RD, Hsu K, Lipshultz LI. Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism. Expert Opin Investig Drugs. 2016;25(10):1233-1240. PMC5009465. (Comprehensive clinical review.) | human study |
| 2014 | Enclomiphene Citrate | Wiehle RD, Fontenot GK, Hsu K, Lipshultz L. Oral Enclomiphene Citrate Stimulates the Endogenous Production of Testosterone and Sperm Counts in Men with Low Testosterone: Comparison with Testosterone Gel. J Sex Med. 2014;11(5):1208-1218. | human study |
| 2013 | Enclomiphene Citrate | Kaminetsky J, Werner M, Fontenot G, Wiehle RD. Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel. J Sex Med. 2013;10(6):1628-1635. | human study |
| 2013 | Enclomiphene Citrate | Wiehle RD, Fontenot GK. Oral enclomiphene citrate lowers IGF-1 in men with secondary hypogonadism while raising testosterone: implications for cancer prevention. Cancer Res. 2013;73(8 Supplement):1326. (AACR abstract.) | human study |
| 2009 | Enclomiphene Citrate | Hill S, Arutchelvam V, Quinton R. Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men. IDrugs. 2009;12(2):109-119. (Foundational enclomiphene clinical pharmacology paper.) | human study |
| 2003 | Enclomiphene Citrate | Guay AT, Jacobson J, Perez JB, Hodge MB, Velasquez E. Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit? Int J Impot Res. 2003;15(3):156-165. | human study |
| 2013 | Enclomiphene Citrate | Wiehle RD, Fontenot GK, Wike J, Hsu K, Nydell J, Lipshultz L. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU Int. 2013;112(8):1188-1200. PMC4155868. (PK/PD study; 48 men; 6 weeks.) | pharmacology |
| 2021 | Gonadorelin | Kohn TP, Louis MR, Pickett SM, Lindgren MC, Kohn JR, Pastuszak AW, Lipshultz LI. Effects of subcutaneous gonadotropin-releasing hormone administration on serum hormonal concentrations, semen parameters, and sperm retrieval in men with hypogonadism undergoing testosterone therapy… PMID 33705811 | human study |
| 2002 | Gonadorelin | Pitteloud N, Hayes FJ, Dwyer A, Boepple PA, Lee H, Crowley WF Jr. Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2002;87(9):4128-4136. PMID: 12213860. PMID 12213860 | human study |
| 1994 | Gonadorelin | Filicori M, Flamigni C, Dellai P, Cognigni G, Michelacci L, Arnone R, Sambataro M, Falbo A. Treatment of anovulation with pulsatile gonadotropin-releasing hormone: prognostic factors and clinical results in 600 cycles. J Clin Endocrinol Metab. 1994;79(4):1215-1220. PMID: 7962300. PMID 7962300 | human study |
| 1986 | Gonadorelin | Santoro N, Filicori M, Crowley WF. Hypogonadotropic disorders in men and women: diagnosis and therapy with pulsatile gonadotropin-releasing hormone. Endocr Rev. 1986;7(1):11-23. PMID: 3082643. (Pulsatile GnRH therapy review.) PMID 3082643 | human study |
| 1982 | Gonadorelin | Hoffman AR, Crowley WF. Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormone. N Engl J Med. 1982;307(20):1237-1241. PMID: 6811941. (Pivotal pulsatile GnRH clinical paper.) PMID 6811941 | human study |
| 1971 | Gonadorelin | Matsuo H, Baba Y, Nair RM, Arimura A, Schally AV. Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence. Biochem Biophys Res Commun. 1971;43(6):1334-1339. PMID: 4936338. (GnRH primary structure.) PMID 4936338 | preclinical, in vivo |
| 1971 | Gonadorelin | Schally AV, Arimura A, Baba Y, Nair RM, Matsuo H, Redding TW, Debeljuk L. Isolation and properties of the FSH and LH-releasing hormone. Biochem Biophys Res Commun. 1971;43(2):393-399. PMID: 4930263. (Schally GnRH isolation paper — Nobel Prize 1977.) PMID 4930263 | mechanism / discovery |
| 2026 | Gonadorelin | WADA Prohibited List 2026. World Anti-Doping Agency. wada-ama.org. (Gonadorelin banned in males under S2.2.) | regulatory / registry |
| — | Gonadorelin | FDA. Factrel (gonadorelin hydrochloride) Prescribing Information. FDA.gov. Wyeth Ayerst (discontinued). (Historical FDA approval reference.) | regulatory / registry |
| — | Gonadorelin | FDA. Lutrepulse / Lutrelef (gonadorelin acetate) Prescribing Information. FDA.gov. Ferring (discontinued). (Historical FDA pulsatile-pump approval.) | regulatory / registry |
| 2015 | Gonadorelin | Ramasamy R, Armstrong JM, Lipshultz LI. Preserving fertility in the hypogonadal patient: an update. Asian J Androl. 2015;17(2):197-200. PMID: 25337841. (TRT fertility preservation review — HCG context.) PMID 25337841 | research article |
| 2014 | Gonadorelin | Rahnema CD, Lipshultz LI, Crosnoe LE, Kovac JR, Kim ED. Anabolic steroid-induced hypogonadism: diagnosis and treatment. Fertil Steril. 2014;101(5):1271-1279. PMID: 24636400. (Context for modern HPG preservation strategies.) PMID 24636400 | research article |
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Frequently asked
Have Enclomiphene Citrate and Gonadorelin been studied together?
Researchers have published mechanistic-level co-administration discussion of Enclomiphene Citrate and Gonadorelin. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Enclomiphene Citrate and Gonadorelin share?
Enclomiphene Citrate and Gonadorelin do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Enclomiphene Citrate and Gonadorelin?
Enclomiphene Citrate: CRL Dec 2015; not approved. Gonadorelin: Historical approval (Factrel, Lutrepulse); compounded off-label currently. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Enclomiphene Citrate and Gonadorelin?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Enclomiphene Citrate profile and the Gonadorelin profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026