Pair page
Thymagen with Thymalin
Mechanism-tag overlap and published literature for Thymagen and Thymalin, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
khavinson-thymic-immune-bioregulator
thymic-polypeptide-bioregulator-complex
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Thymagen and Thymalin have published these mechanism-level observations. Not a co-administration recommendation.
The natural calf-thymus peptide complex from which Thymagen was originally isolated. Russian clinical practice sometimes layers Thymagen (oral dipeptide, EW) as maintenance between Thymalin (parenteral complex) intensive courses. Mechanistically related — Thymagen is one of the defined active components of Thymalin — rather than mechanistically independent.
Quick facts
Thymagen
Thymalin
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2021 | Thymagen | Khavinson VK, Linkova NS, Kukanova EO, Bolshakova AV, Gainullina AN. Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19. Stem Cell Rev Rep. 2021. PMID: 33575961. PMID 33575961 | human study |
| 1996 | Thymagen | Zhuk EA, Galenok VA. Timogen v lechenii sakharnogo diabeta I tipa [Thymogen in the treatment of type-1 diabetes mellitus]. Ter Arkh. 1996;68(10):12-14. Russian. PMID: 9026934. PMID 9026934 | human study |
| 2001 | Thymagen | Anisimov VN, Khavinson VKh, Morozov VG. Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats. Biogerontology. 2001;2(1):47-55. PMID: 11707921. (Chronic rodent dosing — longevity and anti-carcinogenesis signal.) PMID 11707921 | preclinical, in vivo |
| 1989 | Thymagen | Bespalov VG, Troian DN, Petrov AS, Morozov VG, Khavinson VKh. Ingibiruiushchii effekt timogena na razvitie opukholei pishchevoda i predzheludka, indutsirovannykh etilovym efirom N-nitrozosarkozina u krys [Inhibiting effect of thymogen on the development of tumors of the esophagu… PMID 2759010 | preclinical, in vivo |
| 2022 | Thymagen | Khavinson VK, Linkova NS, Kukanova EO, Bolshakova AV, Gainullina AN, Tendler SM, Morozov VG, Tarnovskaya SI, Vanyushin BF, Shataeva LK, Bakaeva ZV. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci. 202… | preclinical, in vitro |
| 2021 | Thymagen | Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide regulation of cell differentiation, gene expression, and protein synthesis. Bull Exp Biol Med. 2021;170(5):707-711. | mechanism / discovery |
| 2003 | Thymagen | Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. PMID: 12937678. (Methodological style of Khavinson mechanistic papers.) PMID 12937678 | mechanism / discovery |
| 1997 | Thymagen | Kozlov VA, Khavinson VKh. Natural and synthetic thymic peptides as therapeutics for immune dysfunction. Int Immunopharmacol. 1997;19(9-10):501-505. doi:10.1016/S0192-0561(97)00058-1. (Foundational Western-indexed characterization of Thymalin and Thymogen.) | mechanism / discovery |
| 1997 | Thymagen | Morozov VG, Khavinson VKh. Natural and synthetic thymic peptides: isolation, structure, and biological activity. Int J Immunopharmacol. 1997;19(9-10):501-505. (Original characterization.) | mechanism / discovery |
| 2002 | Thymagen | Khavinson VK. Peptides and Ageing. Neuroendocrinol Lett. 2002;23 Suppl 3:11-144. PMID: 12374906. (Foundational review of the Khavinson peptide bioregulator program.) PMID 12374906 | review |
| 2025 | Thymagen | FDA. Bulk Drug Substances Nominated for Use in Compounding under Section 503A of the Federal Food, Drug, and Cosmetic Act. FDA.gov. Updated 2025–2026 (Thymagen / EW dipeptide / Thymogen not listed). | regulatory / registry |
| 2011 | Thymagen | Khavinson VK, Linkova NS, Trofimov AV, Polyakova VO, Sevostyanova NN, Kvetnoy IM. Morphofunctional fundamentals for peptide regulation of aging. Biogerontology. 2011;12(2):95-106. (Supporting mechanistic framework.) | bioregulator literature |
| 2020 | Thymalin | Khavinson V, Linkova N, Dyatlova A, Kuznik B, Umnov R. Peptides: Prospects for Use in the Treatment of COVID-19. Molecules. 2020 Sep 24;25(19):4389. doi: 10.3390/molecules25194389. PMID: 32987757. (Computational and mechanistic review of Khavinson short peptides — including the… PMID 32987757 | human study |
| 2020 | Thymalin | Khavinson VK, Kuznik BI, Volchkov VA, Rukavishnikova SA, Titova ON, Akhmedov TA, Trofimova SV, Ryzhak GA, Potyomkin VV, Saginbaev UR. Effect of thymalin on adaptive immunity in complex therapy for patients with COVID-19. Klinicheskaya Meditsina (Russian Journal). 2020;98(8):593-… | human study |
| 2020 | Thymalin | Lukyanov SA, Kuznik BI, Shapovalov KG, Khavinson VK, Smolyakov YN, et al. Thymalin as a Potential Alternative in the Treatment of Severe Acute Respiratory Infection Associated with SARS-CoV-2. Int J Immunol Immunother. 2020;7:055. (Severe-COVID-19 case treated with Thymalin 10 m… | human study |
| 2003 | Thymalin | Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003 Jun-Aug;24(3-4):233-240. PMID: 14523363. (266-patient elderly geroprotective trial; 6–8-year follow-up; mortality reductions of 2.0-fold for Thymalin alone, 2.5-fold fo… PMID 14523363 | human study |
| 1986 | Thymalin | Kuznik BI, Makhakova GCh, Morozov VG, Pisarevskaia LI, Khavinson VKh. [Effect of thymalin on thrombocyte aggregation and the antiaggregation activity of the vascular wall in intact and thymectomized rats]. Biull Eksp Biol Med. 1986 Aug;102(8):200-202. Russian. PMID: 3754821. (Ea… PMID 3754821 | preclinical, in vivo |
| 1982 | Thymalin | Anisimov VN, Khavinson VKh, Morozov VG. Carcinogenesis and aging. IV. Effect of low-molecular-weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice. Mech Ageing Dev. 1982 Jul;19(3):245-258. doi: 10.1016/0047-63… | preclinical, in vivo |
| 2022 | Thymalin | Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, Mironova E, Pulcini R, Robuffo I, Bologna G, Simeone P, Lanuti P, Guarnieri S, Trofimova S, Procopio AD, Toniato E. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macr… PMID 35408963 | preclinical, in vitro |
| 2020 | Thymalin | Khavinson VK, Linkova NS, Kvetnoy IM, Polyakova VO, Drobintseva AO, Kvetnaya TV, Ivko OM. Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells. Bull Exp Biol Med. 2020 Nov;170(1):118-122. doi: 10.1007/s10517-020-05016-z. PMID: 33237528. (In vitro demonstrati… PMID 33237528 | preclinical, in vitro |
| 2016 | Thymalin | Linkova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, Khavinson VK. Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro. Bull Exp Biol Med. 2016 May;161(1):175-178. doi: 10.1007/s10517-016-3370-x. PMID: 27259484. (Khavinson short… PMID 27259484 | preclinical, in vitro |
| 2017 | Thymalin | Khavinson V, Popovich I. Short Peptides Regulate Gene Expression, Protein Synthesis and Enhance Life Span. In: Vaiserman AM (ed.). Anti-aging Drugs: From Basic Research to Clinical Practice. RSC Drug Discovery Series No. 57. Royal Society of Chemistry; 2017. Chapter 20, pp. 496–… | mechanism / discovery |
| 2016 | Thymalin | Khavinson VK, Lin'kova NS, Tarnovskaya SI. Short Peptides Regulate Gene Expression. Bull Exp Biol Med. 2016 Nov;162(2):288-292. doi: 10.1007/s10517-016-3596-7. PMID: 27909961. (Khavinson group's short-peptide DNA-binding / gene-expression-regulation hypothesis, the mechanistic f… PMID 27909961 | mechanism / discovery |
| 2021 | Thymalin | Khavinson VK, Linkova NS, Kvetnoy IM, Kvetnaia TV, Polyakova VO, Ashapkin VV. The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity. Front Pharmacol. 2021;12:716947. doi: 10.3389/fphar.2021.716947. PMC8365293. (Narrative review summarizing 6–12-ye… | review |
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Frequently asked
Have Thymagen and Thymalin been studied together?
Researchers have published mechanistic-level co-administration discussion of Thymagen and Thymalin. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Thymagen and Thymalin share?
Thymagen and Thymalin do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Thymagen and Thymalin?
Thymagen: Not approved. Thymalin: Not approved (US). FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Thymagen and Thymalin?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Thymagen profile and the Thymalin profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026