Sermorelin with Testosterone

The receipt

Evidence on the combination

Human pilots

Sigalos et al., 2017

What each does alone

• Muscle & strength · Daily shotSermorelinGH secretagogueThe first FDA-approved growth-hormone releaser, now compounded for adults. The approval was for kids, 1997.Controlled trialsCompounded RxChecked Oct 18
• Libido & hormones · Weekly shotTestosteroneHormonePrescribed for low testosterone; also the original anabolic steroid. Normal is 300–1,000 ng/dL.Approved drugFDA approvedChecked Oct 23

Mechanism overlap · reasoning, not evidence

Sermorelin

Peptide — GHRH Analog, Growth Hormone Secretagogue

Testosterone

Androgen — Primary Male Sex Hormone

Reasoning, not evidence: what each is described to do says nothing about what they do together.

What the studies found

Men on testosterone therapy (Sigalos et al., 2017)

• What was given — A retrospective review of 105 hypogonadal men on testosterone therapy who were prescribed GHRP-6, GHRP-2 and sermorelin together, 100 mcg of each injected under the skin three times a day (started 2012–2015). 14 men met the strict compliance criteria and were analysed.
• What it found — IGF-1 rose from 159.5 to 239.0 ng/mL (p < .0001) over a mean 134 days of treatment. Men also taking an aromatase inhibitor or tamoxifen had smaller rises. In the full text, testosterone and free testosterone rose significantly from 90 days on; LH, FSH and estradiol did not change.
• Limits — No control group, and the three peptides were always given together, so no single peptide's effect can be separated. Anthropometric data were missing for most men.

No study has added sermorelin alone to testosterone therapy.