GHRP-2 with Sermorelin

The receipt

Evidence on the combination

Human pilots

Tiulpakov et al., 1995 · Sigalos et al., 2017

What each does alone

• Muscle & strength · Daily shotGHRP-2GH secretagogueClinic users inject it 2–3 times a day. Its only approval: a one-shot growth-hormone test in Japan, 2004.Controlled trialsGray marketChecked Oct 18
• Muscle & strength · Daily shotSermorelinGH secretagogueThe first FDA-approved growth-hormone releaser, now compounded for adults. The approval was for kids, 1997.Controlled trialsCompounded RxChecked Oct 18

Mechanism overlap · reasoning, not evidence

GHRP-2

Peptide — Growth Hormone Secretagogue (Ghrelin Receptor Agonist)

Sermorelin

Peptide — GHRH Analog, Growth Hormone Secretagogue

Reasoning, not evidence: what each is described to do says nothing about what they do together.

What the studies found

Healthy young men, single doses (Tiulpakov et al., 1995)

• What was given — 8 healthy men aged 25–34, each given in random order an IV dose of GHRH(1-29)NH2, the molecule sold as sermorelin, an IV dose of GHRP-2, and both together (1 mcg/kg each).
• What it found — Growth hormone peaked 20–45 minutes after each dose. Together the two released more than GHRP-2 alone, but no more than the two separate responses added up; GHRP-2 alone released about three times as much as GHRH.
• Limits — Single doses in eight men; the authors note that GHRP-2 was given in a larger molar amount than GHRH, which may have masked GHRH's share.

Men on testosterone therapy (Sigalos et al., 2017)

• What was given — A retrospective review of 105 hypogonadal men on testosterone therapy who were prescribed GHRP-6, GHRP-2 and sermorelin together, 100 mcg of each injected under the skin three times a day (started 2012–2015). 14 men met the strict compliance criteria and were analysed.
• What it found — IGF-1 rose from 159.5 to 239.0 ng/mL (p < .0001) over a mean 134 days of treatment. Men also taking an aromatase inhibitor or tamoxifen had smaller rises. In the full text, testosterone and free testosterone rose significantly from 90 days on; LH, FSH and estradiol did not change.
• Limits — No control group, and the three peptides were always given together, so no single peptide's effect can be separated. Anthropometric data were missing for most men.