Pair page
Palmitoyl Dipeptide-6 with Rigin
Mechanism-tag overlap and published literature for Palmitoyl Dipeptide-6 and Rigin, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
cosmetic-skin-firming-lipopeptide
cosmetic-immune-modulating-tetrapeptide
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Palmitoyl Dipeptide-6 and Rigin have published these mechanism-level observations. Not a co-administration recommendation.
Another palmitoyl lipopeptide marketed for anti-inflammatory cytokine-modulating effects (claimed inhibition of interleukin-6 release). Sharing the palmitoyl delivery platform with Palmitoyl Dipeptide-6, Rigin is often blended in the same finished product as part of a "mature skin" or "sensitive anti-aging" peptide complex.
Layering multiple signal peptides in a single formulation is standard multi-peptide anti-aging formulation practice, built on the theory (limited rigorous evidence) that each peptide engages a different receptor / signal axis and the combination provides additive or synergistic benefit.
Quick facts
Palmitoyl Dipeptide-6
Rigin
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2014 | Palmitoyl Dipeptide-6 | Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. PMID: 23949208. (Oral collagen-pe… PMID 23949208 | human trial |
| 2012 | Palmitoyl Dipeptide-6 | Wakao T, Oyama H, Hara D, Nakaseko T, Kimura S, Wakabayashi H. Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy. J Rehabil Med. 2012;44(10):888-891. PMID: 23146065. (Small pilot demonstrating a cosmetic… PMID 23146065 | human pilot |
| 1993 | Palmitoyl Dipeptide-6 | Katayama K, Armendariz-Borunda J, Raghow R, Kang AH, Seyer JM. A pentapeptide from type I procollagen promotes extracellular matrix production. J Biol Chem. 1993;268(14):9941-9944. PMID: 8486721. (Founding in-vitro demonstration that the KTTKS pentapeptide stimulates type I coll… PMID 8486721 | preclinical, in vitro |
| 2013 | Palmitoyl Dipeptide-6 | Castelletto V, Hamley IW, Whitehouse C, Matts PJ, Osborne R, Baker ES. Self-Assembly of Palmitoyl Lipopeptides Used in Skin Care Products. Langmuir. 2013;29(29):9149-9155. DOI: 10.1021/la401771j. (Biophysical characterization of pal-KTTKS, pal-GHK, and pal-KT self-assembly — est… | mechanism / discovery |
| 2020 | Palmitoyl Dipeptide-6 | Errante F, Ledwoń P, Latajka R, Rovero P, Papini AM. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020;8:572923. DOI: 10.3389/fchem.2020.572923. (Contemporary review of cosmeceutical peptide chemistry, delivery, and regulatory frameworks.… | review |
| 2017 | Palmitoyl Dipeptide-6 | Pai VV, Bhandari P, Shukla P. Topical peptides as cosmeceuticals. Indian J Dermatol Venereol Leprol. 2017;83(1):9-18. DOI: 10.4103/0378-6323.186500. (Narrative review of topical peptide cosmeceuticals including palmitoyl lipopeptides; evaluates evidence and regulatory framework… | review |
| 2011 | Palmitoyl Dipeptide-6 | Abu Samah NH, Heard CM. Topically applied KTTKS: a review. Int J Cosmet Sci. 2011;33(6):483-490. PMID: 21535443. (Comprehensive academic review of KTTKS and its major derivatives including palmitoylated forms. Addresses physicochemical properties, theoretical skin permeation, an… PMID 21535443 | review |
| 2009 | Palmitoyl Dipeptide-6 | Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009;31(5):327-345. DOI: 10.1111/j.1468-2494.2009.00490.x. (Review of topical peptide cosmetics with evidence-rating discussion across the signal / neurotransmitter / carrier p… | review |
| 2009 | Palmitoyl Dipeptide-6 | Fields K, Falla TJ, Rodan K, Bush L. Bioactive peptides: signaling the future. J Cosmet Dermatol. 2009;8(1):8-13. DOI: 10.1111/j.1473-2165.2009.00416.x. (Review of bioactive peptides in dermatology, including discussion of signal peptides and palmitoyl lipopeptides as the leadin… | review |
| 2009 | Palmitoyl Dipeptide-6 | Zhang L, Falla TJ. Cosmeceuticals and peptides. Clin Dermatol. 2009;27(5):485-494. DOI: 10.1016/j.clindermatol.2009.05.013. (Review specifically on cosmetic peptides from a dermatology-clinic perspective, addressing the signal-peptide class including palmitoylated variants.) | review |
| 2000 | Palmitoyl Dipeptide-6 | Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci. 2000;22(3):207-218. PMID: 18503476. (Sederma's foundational review establishing the cosmetic-lipopeptide strategic framework — palmitoylati… PMID 18503476 | industry documentation |
| 2007 | Palmitoyl Dipeptide-6 | Lupo MP, Cole AL. Cosmeceutical peptides. Dermatol Ther. 2007;20(5):343-349. PMID: 18045359. (Dermatology-review classification of cosmetic peptides into signal, neurotransmitter-affecting, and carrier categories. Notes the limited efficacy-testing rigor of the field as a whole.) PMID 18045359 | research article |
| 2002 | Rigin | Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. PMID: 18498523. (Foundational cosmetic peptide characte… PMID 18498523 | mechanism / discovery |
| 2021 | Rigin | Ferreira MSM, Sousa Lobo JM, Almeida IF. Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel). 2021;14(8):702. PMID: 34358128. (Review of cosmetic peptide use in sensitive-skin formulations, with mechanistic discussion of palmitoyl tetrapeptide-7'… PMID 34358128 | review |
| 2020 | Rigin | Ferreira MS, Magalhães MC, Sousa Lobo JM, Almeida IF. Trending Anti-Aging Peptides. Cosmetics. 2020;7(4):91. doi:10.3390/cosmetics7040091. (Review of the current cosmetic peptide landscape with detailed discussion of palmitoyl tetrapeptide-7 mechanism claims.) | review |
| 2012 | Rigin | Reddy BY, Jow T, Hantash BM. Bioactive oligopeptides in dermatology: Part I. Exp Dermatol. 2012;21(8):563-568. PMID: 22672785. (Review of bioactive oligopeptides in dermatology including cosmetic palmitoyl-conjugate peptides.) PMID 22672785 | review |
| 2009 | Rigin | Zhang L, Falla TJ. Cosmeceuticals and peptides. Clin Dermatol. 2009;27(5):485-494. PMID: 19695480. (Cosmeceutical peptide review discussing palmitoyl tetrapeptide-7 positioning within the signal / neurotransmitter / carrier peptide framework.) PMID 19695480 | review |
| 2006 | Rigin | Maggio M, Guralnik JM, Longo DL, Ferrucci L. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci. 2006;61(6):575-584. PMID: 16799139. (Foundational review of IL-6 in aging — the biological plausibility case for Rigin's anti-inflammagi… PMID 16799139 | review |
| 2005 | Rigin | Lupo MP. Cosmeceutical peptides. Dermatol Surg. 2005;31(7 Pt 2):832-836; discussion 836. PMID: 16029675. (Widely cited academic review of the cosmeceutical peptide class including signal peptides, neurotransmitter-acting peptides, and carrier peptides.) PMID 16029675 | review |
| 1987 | Rigin | Rocchi R, Biondi L, Filira F, Gobbo M, Dagan S, Fridkin M. Synthesis and biological activity of tuftsin and rigin derivatives containing monosaccharides or monosaccharide derivatives. Int J Pept Protein Res. 1987;29(2):250-261. PMID: 3570655. (Classic synthesis and biological ch… PMID 3570655 | industry documentation |
| 2020 | Rigin | Errante F, Ledwoń P, Latajka R, Rovero P, Papini AM. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020;8:572923. PMID: 33195067. (Cosmetic peptide overview referencing palmitoyl tetrapeptide-7 within the broader framework of synthetic cosm… PMID 33195067 | research article |
| 2018 | Rigin | Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14(10):576-590. PMID: 30046148. (Inflammaging framework citation — the broader biological context for cosmetic anti-infla… PMID 30046148 | research article |
| 2015 | Rigin | Hoppel M, Reznicek G, Kählig H, Kotisch H, Resch GP, Valenta C. Topical delivery of acetyl hexapeptide-8 from different emulsions: Influence of emulsion composition and internal structure. Eur J Pharm Sci. 2015;68:27-35. PMID: 25433250. (Methodologically adjacent cosmetic peptid… PMID 25433250 | research article |
| 2009 | Rigin | Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009;31(5):327-345. PMID: 19570043. (Cosmetic peptide topical-delivery review — stratum corneum penetration, palmitoyl conjugate strategy, and mechanism-by-mechanism evidence i… PMID 19570043 | research article |
Related pair pages
More research context
Frequently asked
Have Palmitoyl Dipeptide-6 and Rigin been studied together?
Researchers have published mechanistic-level co-administration discussion of Palmitoyl Dipeptide-6 and Rigin. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Palmitoyl Dipeptide-6 and Rigin share?
Palmitoyl Dipeptide-6 and Rigin do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Palmitoyl Dipeptide-6 and Rigin?
Palmitoyl Dipeptide-6: Cosmetic ingredient. Rigin: Cosmetic ingredient. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Palmitoyl Dipeptide-6 and Rigin?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Palmitoyl Dipeptide-6 profile and the Rigin profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026