Hexarelin with Sermorelin

The receipt

Evidence on the combination

Human pilots

Massoud et al., Clin Endocrinol 1996 · Massoud et al., J Clin Endocrinol Metab 1996 · Giustina et al., 1996

What each does alone

• Muscle & strength · Daily shotHexarelinGH secretagogueKnown for the biggest growth-hormone pulse of its family. The catch: it fades within 2–4 weeks of daily use.Human pilotsGray marketChecked Oct 18
• Muscle & strength · Daily shotSermorelinGH secretagogueThe first FDA-approved growth-hormone releaser, now compounded for adults. The approval was for kids, 1997.Controlled trialsCompounded RxChecked Oct 18

Mechanism overlap · reasoning, not evidence

Hexarelin

Peptide — GHRP (Growth Hormone-Releasing Peptide)

Sermorelin

Peptide — GHRH Analog, Growth Hormone Secretagogue

Reasoning, not evidence: what each is described to do says nothing about what they do together.

What the studies found

Healthy men, repeated IV doses (Massoud et al., Clin Endocrinol 1996)

• What was given — 6 healthy men; IV hexarelin 1 µg/kg, GHRH(1-29)NH2 1 µg/kg, or both, each repeated 60 or 120 minutes later.
• What it found — Peak GH secretion with both was greater than the sum of each alone (P = 0.001). A second dose 120 minutes later gave less, and the synergy was lost on repeat doses.
• Limits — 6 men, single-day lab studies.

Healthy men, low-dose hexarelin (Massoud et al., J Clin Endocrinol Metab 1996)

• What was given — Healthy adult men; GHRH(1-29)NH2 1.0 µg/kg alone or with a low dose of hexarelin (0.125 µg/kg).
• What it found — Together they produced “massive GH release” (115 mU/L), a moderate prolactin rise (84.9%) and no rise in cortisol.

Men with type 1 diabetes (Giustina et al., 1996)

• What was given — 10 men with type 1 diabetes and 7 healthy men; IV hexarelin 100 µg, GHRH(1-29)NH2 100 µg, or both.
• What it found — GH rose more with both than with either alone: synergistic in the healthy men, additive in the men with diabetes.

The studies used single IV doses in a lab, not the daily injections people run.