Pair page
Epithalon with Ovagen
Mechanism-tag overlap and published literature for Epithalon and Ovagen, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
pineal-tetrapeptide-khavinson-bioregulator
hepato-gikhavinson-tripeptide-bioregulator
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Epithalon and Ovagen have published these mechanism-level observations. Not a co-administration recommendation.
The flagship Khavinson bioregulator — pineal / telomerase claims. Common longevity-stack companion to Ovagen in Khavinson practice.
Quick facts
Epithalon
Ovagen
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2010 | Epithalon | Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector Epitalamin: effects on vascular endothelial function in elderly patients. Adv Gerontol. 2010;23(3):440-446. | human study |
| 2004 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004;137(5):503-506. | human study |
| 2003 | Epithalon | Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. PMID: 14523363. (266-patient elderly mortality cohort.) PMID 14523363 | human study |
| 2021 | Epithalon | Khavinson V, Ilina A, Kraskovskaya N, Linkova N, Kolchina N, Mikhailova N, Petukhov M. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel). 2021;14(6):515. | preclinical, in vivo |
| 2004 | Epithalon | Labunets IF, Butenko GM, Dragunova VA, Magdich LV, Khavinson VKh. Effect of epithalamin, thymalin, and tocopherol on age-associated involution of the pineal gland in rats. Bull Exp Biol Med. 2004;137(5):510-512. | preclinical, in vivo |
| 2003 | Epithalon | Anisimov VN, Khavinson VKh, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4)… PMID 14501183 | preclinical, in vivo |
| 2003 | Epithalon | Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. Int J Mol Med. 2003;12(4):473-477. PMID: 12964019. PMID 12964019 | preclinical, in vivo |
| 2025 | Epithalon | Al-Dulaimi MS, et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. 2025. PMID: 40908429. PMC12411320. (Modern Western-lab replication of the central telomerase-activation claim.) PMID 40908429 | mechanism / discovery |
| 2017 | Epithalon | Khavinson V, Popovich I. Short peptides regulate gene expression, protein synthesis and enhance life span. In: Understanding the Aging Process and Age-Related Diseases. Academic Press; 2017. | mechanism / discovery |
| 2016 | Epithalon | Khavinson VKh, Linkova NS, Tarnovskaia SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288-292. | mechanism / discovery |
| 2003 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bull Exp Biol Med. 2003;135(6):590-592. PMID: 12937682. PMID 12937682 | mechanism / discovery |
| 2017 | Epithalon | Khavinson VKh, Kopylov AT, Vaskovsky BV, Ryzhak GA, Lin'kova NS. Identification of peptide AEDG in the polypeptide complex of the pineal gland. Bull Exp Biol Med. 2017;164(1):41-43. | bioregulator literature |
| 2021 | Ovagen | Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053. PMID: 34834147. PMID 34834147 | systematic review |
| 2012 | Ovagen | Arutjunyan AV, Kozina LS, Stvolinskii SL, Bulygina YR, Mashkina AP, Khavinson VK. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5(2):179-185. PMID: 22567177. PMID 22567177 | preclinical, in vivo |
| 2001 | Ovagen | Khavinson VKh, Yakovleva NG, Popuchiev VV, Kvetnoi IM, Manokhina RP. Reparative effect of epithalon on ovarian function in old rats. Bull Exp Biol Med. 2001;132(6):1155-1158. PMID: 11875579. (Epithalon work illustrating Khavinson tissue-specific hypothesis; not Ovagen but concep… PMID 11875579 | preclinical, in vivo |
| 2014 | Ovagen | Khavinson VK, Soloviev AY, Zhilinskiy DV, Shataeva LK, Bondarev IE. Peptide regulation of gene expression and protein synthesis in bronchial epithelium. Lung. 2014;192(5):781-791. PMID: 25064400. PMID 25064400 | mechanism / discovery |
| 2012 | Ovagen | Khavinson VK, Lin'kova NS, Kvetnoi IM, Kvetnaia TV, Polyakova VO, Korf HW. Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture. Bull Exp Biol Med. 2012;153(2):255-258. PMID: 22816105. PMID 22816105 | mechanism / discovery |
| 2014 | Ovagen | Khavinson VK. Tetrapeptide as a geroprotector. Nanotechnol Rev. 2014;3(2):153-165. (Khavinson perspective on short peptide bioregulators.) | review |
| 2013 | Ovagen | Khavinson VKh, Kuznik BI, Ryzhak GA. Peptide bioregulators: the new class of geroprotectors. Message 2. Clinical studies results. Adv Gerontol. 2013;26(1):20-37. PMID: 24003726. (Broader Khavinson-group review of the peptide bioregulator family.) PMID 24003726 | review |
| 2012 | Ovagen | Linkova NS, Polyakova VO, Trofimov AV, Sevostyanova NN, Kvetnoy IM. Peptides as epigenetic regulators: role in aging and diseases. Adv Gerontol. 2012;25(2):215-220. (Khavinson-group perspective on peptide epigenetics.) | review |
| 2016 | Ovagen | Khavinson VKh, Ashapkin VV, Vanyushin BF. Short peptides and telomere length regulator drug Epithalon. In: DNA Methylation and Complex Human Disease. Academic Press; 2016:173-188. (Book chapter framing the Khavinson bioregulator hypothesis in the context of epigenetics.) | bioregulator literature |
| 2014 | Ovagen | Khavinson VK. Peptide regulation of aging: 35-year research experience. Bull Exp Biol Med. 2014;157(1):79-82. PMID: 24915933. PMID 24915933 | bioregulator literature |
| 2011 | Ovagen | Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, Boldyrev A. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011;14(5):535-541. PMID: 21978082. (Pinealon — Pinealon… PMID 21978082 | bioregulator literature |
| 2010 | Ovagen | Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149. PMID: 19609712. PMID 19609712 | bioregulator literature |
Related pair pages
More research context
Frequently asked
Have Epithalon and Ovagen been studied together?
Researchers have published mechanistic-level co-administration discussion of Epithalon and Ovagen. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Epithalon and Ovagen share?
Epithalon and Ovagen do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Epithalon and Ovagen?
Epithalon: Not approved. Ovagen: Not approved. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Epithalon and Ovagen?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Epithalon profile and the Ovagen profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026