Pair page
DSIP with Epithalon
Mechanism-tag overlap and published literature for DSIP and Epithalon, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
neuroregulatory-nonapeptide-historical-sleep-factor
pineal-tetrapeptide-khavinson-bioregulator
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying DSIP and Epithalon have published these mechanism-level observations. Not a co-administration recommendation.
Khavinson tetrapeptide with proposed pineal-gland / circadian-rhythm effects. Conceptually complementary to DSIP in longevity-plus-sleep community protocols.
Quick facts
DSIP
Epithalon
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 1992 | DSIP | Kaeser HE, Mouret J, Helmert DS. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Eur Neurol. 1992;32(Suppl 1):22-27. PMID: 1299794. (Double-blind negative/marginal result for chronic insomnia.) PMID 1299794 | human trial |
| 1984 | DSIP | Larbig W, Gerber WD, Kluck M, Schoenenberger GA. Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study. Eur Neurol. 1984;23(5):372-385. | human pilot |
| 1995 | DSIP | Vgontzas AN, Friedman TC, Chrousos GP, Bixler EO, Vela-Bueno A, Kales A. Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy. J Sleep Res. 1995;4(S1):224-229. (Observational peptide-level study.) | human study |
| 1984 | DSIP | Dick P, Costa C, Fayolle K, Grandjean ME, Khoshbeen A, Tissot R. DSIP in the treatment of withdrawal syndromes from alcohol and opiates. Eur Neurol. 1984;23(5):364-371. PMID: 6548969. (The 107-patient alcohol/opiate withdrawal study.) PMID 6548969 | human study |
| 1984 | DSIP | Dick P, Costa C, Fayolle K, Grandjean ME, Khoshbeen A, Tissot R. Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors. Psychoneuroendocrinology. 1984;9(1):83-89. PMID: 6328354. PMID 6328354 | human study |
| 1992 | DSIP | Salieva RM, Ivanov DS, Lastochkina NA. Delta sleep-inducing peptide as a factor increasing the content of substance P in the hypothalamus and the resistance of rats to emotional stress. Neurosci Behav Physiol. 1992;22(4):275-279. (Stress-resistance rodent paper.) | preclinical, in vivo |
| 1985 | DSIP | Graf MV, Kastin AJ, Schoenenberger GA. Delta sleep-inducing peptide in spontaneously hypertensive rats. Peptides. 1985;6(6):1043-1046. | preclinical, in vivo |
| 1982 | DSIP | Riou F, Cespuglio R, Jouvet M. Endogenous peptides and sleep in the rat. III. The hypnogenic properties of vasoactive intestinal peptide. Neuropeptides. 1982;2(5):265-277. (Context for sleep-peptide field.) | preclinical, in vivo |
| — | DSIP | Cadelis G, Bove P, Mondon K, Albaret JM. Transport and metabolism of delta sleep-inducing peptide in cultured human intestinal epithelial cell monolayers. (Caco-2 oral-absorption paper.) | preclinical, in vitro |
| 1985 | DSIP | Banks WA, Kastin AJ. Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier. Peptides. 1985;6(1):71-75. (BBB-penetration characterization.) | mechanism / discovery |
| 1977 | DSIP | Monnier M, Dudás B, Prochiantz A. Sleep-inducing factor: a neuropeptide? Nature. 1977;268(5616):152-153. (Foundational isolation paper.) | mechanism / discovery |
| 2006 | DSIP | Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a sleep-inducing agent or a universal homeostasis regulator? Zh Evol Biokhim Fiziol. 2006;42(1):3-10. (Russian-language review, English abstract — recent perspective on DSIP's mechanism and role.) | review |
| 2010 | Epithalon | Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector Epitalamin: effects on vascular endothelial function in elderly patients. Adv Gerontol. 2010;23(3):440-446. | human study |
| 2004 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004;137(5):503-506. | human study |
| 2003 | Epithalon | Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. PMID: 14523363. (266-patient elderly mortality cohort.) PMID 14523363 | human study |
| 2021 | Epithalon | Khavinson V, Ilina A, Kraskovskaya N, Linkova N, Kolchina N, Mikhailova N, Petukhov M. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel). 2021;14(6):515. | preclinical, in vivo |
| 2004 | Epithalon | Labunets IF, Butenko GM, Dragunova VA, Magdich LV, Khavinson VKh. Effect of epithalamin, thymalin, and tocopherol on age-associated involution of the pineal gland in rats. Bull Exp Biol Med. 2004;137(5):510-512. | preclinical, in vivo |
| 2003 | Epithalon | Anisimov VN, Khavinson VKh, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4)… PMID 14501183 | preclinical, in vivo |
| 2003 | Epithalon | Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. Int J Mol Med. 2003;12(4):473-477. PMID: 12964019. PMID 12964019 | preclinical, in vivo |
| 2025 | Epithalon | Al-Dulaimi MS, et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. 2025. PMID: 40908429. PMC12411320. (Modern Western-lab replication of the central telomerase-activation claim.) PMID 40908429 | mechanism / discovery |
| 2017 | Epithalon | Khavinson V, Popovich I. Short peptides regulate gene expression, protein synthesis and enhance life span. In: Understanding the Aging Process and Age-Related Diseases. Academic Press; 2017. | mechanism / discovery |
| 2016 | Epithalon | Khavinson VKh, Linkova NS, Tarnovskaia SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288-292. | mechanism / discovery |
| 2003 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bull Exp Biol Med. 2003;135(6):590-592. PMID: 12937682. PMID 12937682 | mechanism / discovery |
| 2017 | Epithalon | Khavinson VKh, Kopylov AT, Vaskovsky BV, Ryzhak GA, Lin'kova NS. Identification of peptide AEDG in the polypeptide complex of the pineal gland. Bull Exp Biol Med. 2017;164(1):41-43. | bioregulator literature |
Related pair pages
More research context
Frequently asked
Have DSIP and Epithalon been studied together?
Researchers have published mechanistic-level co-administration discussion of DSIP and Epithalon. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do DSIP and Epithalon share?
DSIP and Epithalon do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of DSIP and Epithalon?
DSIP: Not approved. Epithalon: Not approved. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on DSIP and Epithalon?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the DSIP profile and the Epithalon profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026