Pair page
Cortagen with Pinealon
Mechanism-tag overlap and published literature for Cortagen and Pinealon, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
khavinson-cortical-neural-bioregulator
khavinson-brain-tripeptide-bioregulator
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Cortagen and Pinealon have published these mechanism-level observations. Not a co-administration recommendation.
Pinealon (EDR tripeptide) targets pineal-/hippocampal-axis endpoints; Cortagen (AEDP tetrapeptide) targets cortex. Common co-cycled pairing within Khavinson neuro-protocols. Preclinical-only combination.
Quick facts
Cortagen
Pinealon
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2021 | Cortagen | Khavinson VKh, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053. PMID: 34834147. PMID 34834147 | systematic review |
| 2006 | Cortagen | Gumen AV, Kozinets IA, Shanin SN, Malinin VV, Rybakina EG. Production of lymphocyte-activating factors by mouse macrophages during aging and under the effect of short peptides. Bulletin of Experimental Biology and Medicine. 2006;142(3):360-362. PMID: 17266159. PMID 17266159 | preclinical, in vivo |
| 2016 | Cortagen | Linkova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, Khavinson VKh. Peptide regulation of skin fibroblast functions during their aging in vitro. Bulletin of Experimental Biology and Medicine. 2016;161(1):175-178. PMID: 27259486. PMID 27259486 | preclinical, in vitro |
| 2011 | Cortagen | Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and the specific interaction of the peptides with deoxyribooligonucleotides and DNA in vitro. Biochemistry (Moscow). 2011;76(11):1210-1219. PM… PMID 22117548 | preclinical, in vitro |
| 2015 | Cortagen | Gromova OA, Torshin IYu, Kalacheva AG, et al. Cortexin: modern view on the mechanism of action. Neurology, Neuropsychiatry, Psychosomatics. 2015;7(1):88-95. (Russian-language review of Cortexin parent-extract mechanism and clinical use.) | mechanism / discovery |
| 2012 | Cortagen | Khavinson VKh, Solov'ev AIu, Zhilinskii DV. Molecular mechanism of the peptide regulation of gene expression: a review. Advances in Gerontology. 2012;25(3):447-456. PMID: 23289233. PMID 23289233 | mechanism / discovery |
| 2020 | Cortagen | Khavinson V, Linkova N, Diatlova A, Trofimova S. Peptide Regulation of Cell Differentiation. Stem Cell Reviews and Reports. 2020;16(1):118-125. PMID: 31813120. DOI: 10.1007/s12015-019-09938-8. PMID 31813120 | bioregulator literature |
| 2016 | Cortagen | Vanyushin BF, Khavinson VKh. Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity. In: Epigenetics — A Different Way of Looking at Genetics. Springer, 2016. DOI: 10.1007/978-3-319-27186-6_5. | bioregulator literature |
| 2012 | Cortagen | Khavinson VKh, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM. Peptides tissue-specifically stimulate cell differentiation during their aging. Bulletin of Experimental Biology and Medicine. 2012;153(1):148-151. PMID: 22808513. PMID 22808513 | bioregulator literature |
| 2010 | Cortagen | Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149. PMID: 19633997. PMID 19633997 | bioregulator literature |
| 2005 | Cortagen | Khavinson VKh, Malinin VV. Gerontological Aspects of Genome Peptide Regulation. Karger Publishers, Basel, 2005. ISBN 3-8055-7903-3. | bioregulator literature |
| 2002 | Cortagen | Kolosova LI, Moiseeva AB, Turchaninova LN, Malinin VV, Polyakov EL, Nozdrachev AD, Khavinson VKh. The delayed effect of cortagen on the restoration of injured nerve function. Doklady Biological Sciences. 2002;384:183-184. PMID: 12375535. PMID 12375535 | bioregulator literature |
| 2021 | Pinealon | Khavinson V, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053. PMID: 34834146. PMID 34834146 | systematic review |
| 2021 | Pinealon | Khavinson V, Ilina A, Kraskovskaya N, Linkova N, Kolchina N, Mikhailova N, Petukhov M. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel). 2021;14(6):515. PMID: 34071714. PMID 34071714 | preclinical, in vivo |
| 2018 | Pinealon | Klement GA, Hawrysh PJ, Khavinson V, Buck LT. Pinealon's effect on hypoxia tolerance in cultured rat pyramidal neurons. Cell Mol Neurobiol. 2018. | preclinical, in vivo |
| 2017 | Pinealon | Khavinson VKh, Lin'kova NS, Kukanova EO. Neuroprotective Effect of EDR Peptide in Mouse Model of Huntington's Disease. J Neurol Neurosci. 2017. (Khavinson group Huntington's publication.) | preclinical, in vivo |
| 2021 | Pinealon | Khavinson VKh, Kuznik BI, Tarnovskaya SI, Lin'kova NS. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease. Int J Mol Sci. 2021. PMC7795577. | mechanism / discovery |
| 2020 | Pinealon | Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis. Int J Mol Sci. 2020;21(2):609. PMID: 31963526. PMID 31963526 | mechanism / discovery |
| 2020 | Pinealon | Khavinson VKh, Kuznik BI, Trofimova SV, Lin'kova NS. Cortexin and its short peptides AEDG and EDR modulate gene expression of proteins in pathogenesis of Alzheimer's disease. Biomed Khim. 2020. (Parallel framework evidence for Khavinson short-peptide gene-expression paradigm.) | mechanism / discovery |
| 2015 | Pinealon | Ashapkin VV, Linkova NS, Khavinson VK, Vanyushin BF. Epigenetic Mechanisms of Peptidergic Regulation of Gene Expression during Aging of Human Cells. Biochemistry (Mosc). 2015;80(3):310-322. PMID: 25761684. PMID 25761684 | mechanism / discovery |
| 2022 | Pinealon | Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide regulation of aging: methodology and evidence. Bull Exp Biol Med. 2022. | bioregulator literature |
| 2020 | Pinealon | Khavinson V, Linkova N, Diatlova A, Trofimova S. Peptide Regulation of Cell Differentiation, Proliferation, and Apoptosis. Adv Gerontol. 2020;10(2):98-106. | bioregulator literature |
| 2019 | Pinealon | Kolchina N, Khavinson V, Linkova N, Yakutseni P, Petukhov M, Morozova E, Ashapkin V. Systematic search for structural motifs of peptide binding to double-stranded DNA. Nucleic Acids Res. 2019;47(20):10553-10563. PMID: 31584079. PMID 31584079 | bioregulator literature |
| 2017 | Pinealon | Khavinson VKh, Sibarov DA, Tsai PY, Adushkin BV, Ryzhak GA. Short peptides stimulate serotonin release and attenuate hyperexcitation in the hippocampus. Bull Exp Biol Med. 2017;163(4):539-541. | bioregulator literature |
Related pair pages
More research context
Frequently asked
Have Cortagen and Pinealon been studied together?
Researchers have published mechanistic-level co-administration discussion of Cortagen and Pinealon. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Cortagen and Pinealon share?
Cortagen and Pinealon do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Cortagen and Pinealon?
Cortagen: Not approved. Pinealon: Not approved. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Cortagen and Pinealon?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Cortagen profile and the Pinealon profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026