Pair page
N-Acetyl Selank with N-Acetyl Semax
Mechanism-tag overlap and published literature for N-Acetyl Selank and N-Acetyl Semax, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
tuftsin-family-anxiolytic
4-7stabilized-acth-nootropic-analog
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying N-Acetyl Selank and N-Acetyl Semax have published these mechanism-level observations. Not a co-administration recommendation.
The classic stabilized-Russian nootropic pairing — Semax (cognitive drive, BDNF, attention) + Selank (GABA A -allosteric calm, anxiolysis). Pharmacodynamically complementary, used in Russian outpatient practice as a paired course.
Quick facts
N-Acetyl Selank
N-Acetyl Semax
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2008 | N-Acetyl Selank | Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA. Immunomodulatory effects of selank in patients with anxiety-asthenic disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-75. PMID: 18577925. PMID 18577925 | human study |
| 2017 | N-Acetyl Selank | Medvedev VE, Tereshchenko OV, Kost NV, Ter-Israelyan AY, Gushanskaya EV, Chobanu IK, Sokolov OY, Miasoedov NF. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027. PMC5322660. | preclinical, in vivo |
| 2009 | N-Acetyl Selank | Semenova TP, Kozlovskii II, Zakharova NM, Kozlovskaia MM. Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA. Eksp Klin Farmakol. 2009;72(4):6-8. PMID: 19803388. PMID 19803388 | preclinical, in vivo |
| 2008 | N-Acetyl Selank | Inozemtseva LS, Karpenko EA, Dolotov OV, Levitskaya NG, Kamensky AA, Andreeva LA, Grivennikov IA. Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. Dokl Biol Sci. 2008;421:241-243. PMID: 18841774. PMID 18841774 | preclinical, in vivo |
| 2002 | N-Acetyl Selank | Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide selank on an active avoidance reflex in rats. Zh Vyssh Nerv Deiat Im I P Pavlova. 2002;52(5):579-584. PMID: 12449037. PMID 12449037 | preclinical, in vivo |
| 1998 | N-Acetyl Selank | Seredenin SB, Kozlovskaia MM, Blednov IuA, Kozlovskii II, Semenova TP, Czabak-Garbacz R. The anxiolytic action of an analog of the endogenous peptide tuftsin on inbred mice with different phenotypes of the emotional stress reaction. Zh Vyssh Nerv Deiat Im I P Pavlova. 1998;48(1)… PMID 9612605 | preclinical, in vivo |
| 2016 | N-Acetyl Selank | Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016 Feb 18;7:31. PMID: 26924986. PMID 26924986 | research article |
| 2014 | N-Acetyl Selank | Kolomin T, Morozova M, Volkova A, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol Immunol. 2014;58(1):50-55. PMID: 24275703. PMID 24275703 | research article |
| 2010 | N-Acetyl Selank | Andreeva LA, Nagaev IY, Mezentseva MV, Shapoval IM, Podchernyaeva RY, Shcherbenko VE, Potapova LA, Rusakova EV, Miasoedov NF. Antiviral properties of structural fragments of the peptide Selank. Dokl Biol Sci. 2010;431:86-88. PMID: 20506848. PMID 20506848 | research article |
| 2009 | N-Acetyl Selank | Ershov FI, Uchakin PN, Uchakina ON, Mezentseva MV, Alekseeva LA, Miasoedov NF. Antiviral activity of immunomodulator Selank in experimental influenza infection. Vopr Virusol. 2009;54(5):19-24. PMID: 19882898. PMID 19882898 | research article |
| 2008 | N-Acetyl Selank | Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, Serebriakova EV, Siranchieva OA, Andriushenko AV, Telesheva ES, Siuniakov SA, Smulevich AB, Miasoedov NF, Seredenin SB. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the t… PMID 18454096 | research article |
| 2003 | N-Acetyl Selank | Kozlovskaya MM, Kozlovskii II, Val'dman EA, Seredenin SB. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci Behav Physiol. 2003;33(9):853-860. PMID: 14969428. PMID 14969428 | research article |
| 2011 | N-Acetyl Semax | Stavchansky VV, Yuzhakov VV, Botsina AY, Skvortsova VI, Bondurko LN, Tsyganova MG, Limborska SA, Myasoedov NF, Dergunova LV. The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study.… PMID 21409522 | human pilot |
| 2018 | N-Acetyl Semax | Gusev EI, Martynov MY, Kostenko EV, Petrova LV, Bobyreva SN. The efficacy of semax in the treatment of patients at different stages of ischemic stroke. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3. Vyp. 2):61-68. PMID: 29798983. PMID 29798983 | human study |
| 2014 | N-Acetyl Semax | Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014;15… PMID 25476978 | preclinical, in vivo |
| 2006 | N-Acetyl Semax | Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Kamensky AA, Grivennikov IA, Myasoedov NF, Engele J. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression… PMID 16996037 | preclinical, in vivo |
| 2001 | N-Acetyl Semax | Shadrina MI, Dolotov OV, Grivennikov IA, Slominsky PA, Andreeva LA, Inozemtseva LS, Limborska SA, Myasoedov NF. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001;308(2):115-118. PMID: 11457574. PMID 11457574 | preclinical, in vivo |
| 2023 | N-Acetyl Semax | Dergunova LV, Filippenkov IB, Limborska SA, Myasoedov NF. Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries. Genes (Basel). 2023;14(5):953. PMID: 37239312. PMID 37239312 | research article |
| 2005 | N-Acetyl Semax | Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005;30(12):1493-1500. PMID: 16362767. PMID 16362767 | research article |
| 2004 | N-Acetyl Semax | Levitskaya NG, Sebentsova EA, Andreeva LA, Alfeeva LY, Kamenskii AA, Myasoedov NF. Investigation of the spectrum of physiological activities of a heptapeptide analog of ACTH(4-10) — Semax. Neurosci Behav Physiol. 2004;34(4):399-405. PMID: 15341214. PMID 15341214 | research article |
| 1997 | N-Acetyl Semax | Gusev EI, Skvortsova VI, Miasoedov NF, Nezavibat'ko VN, Zhuravleva EIu, Vanichkin AV. Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study). Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(6):26-34. PMID: 11517472. PMID 11517472 | research article |
| 1997 | N-Acetyl Semax | Ashmarin IP, Nezavibat'ko VN, Myasoedov NF, Kamenskii AA, Grivennikov IA, Ponomareva-Stepnaia MA, Andreeva LA, Kaplan AIa, Koshelev VB, Riasina TV. A nootropic adrenocorticotropin analog 4-10-semax (15 years experience in its design and study). Zh Vyssh Nerv Deiat Im I P Pavlova… PMID 9234274 | research article |
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Frequently asked
Have N-Acetyl Selank and N-Acetyl Semax been studied together?
Researchers have published mechanistic-level co-administration discussion of N-Acetyl Selank and N-Acetyl Semax. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do N-Acetyl Selank and N-Acetyl Semax share?
N-Acetyl Selank and N-Acetyl Semax do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of N-Acetyl Selank and N-Acetyl Semax?
N-Acetyl Selank: Not listed. N-Acetyl Semax: Not listed. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on N-Acetyl Selank and N-Acetyl Semax?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the N-Acetyl Selank profile and the N-Acetyl Semax profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026