Pair page
MOTS-c with SLU-PP-332
Mechanism-tag overlap and published literature for MOTS-c and SLU-PP-332, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
mitochondrial-derived-exercise-mimetic
err-pan-agonist-exercise-mimetic
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying MOTS-c and SLU-PP-332 have published these mechanism-level observations. Not a co-administration recommendation.
Mitochondrial-derived peptide that activates AMPK via the folate-methionine cycle. Mechanistically orthogonal to ERR agonism; the two approaches affect overlapping mitochondrial phenotypes from different transcriptional / metabolic entry points. Stack rationale is mechanistic, not evidence-based.
Quick facts
MOTS-c
SLU-PP-332
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2022 | MOTS-c | Ramanjaneya M, Jerobin J, Bettahi I, et al. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022;23(19):11991. PMID: 36233287. PMID 36233287 | human study |
| 2022 | MOTS-c | Yin X, Jing Y, Chen Q, et al. The intraocular expression of MOTS-c in patients with age-related cataracts: Correlation between MOTS-c and lens mitochondrial DNA levels. Clin Exp Ophthalmol. 2022;50(5):498-506. | human study |
| 2018 | MOTS-c | Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018;28(3):516-524.e7. PMID: 29983246. PMID 29983246 | mechanism / discovery |
| 2023 | MOTS-c | Kong BS, Lee C, Cho YM. Mitochondrial-encoded peptide MOTS-c, diabetes, and aging-related diseases. Diabetes Metab J. 2023;47(3):315-327. PMID: 36672073. PMID 36672073 | research article |
| 2021 | MOTS-c | Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470. P… PMID 33473109 | research article |
| 2018 | MOTS-c | Mendelsohn AR, Larrick JW. Mitochondrial-Derived Peptides Exacerbate Senescence. Rejuvenation Res. 2018;21(4):369-373. PMID: 30037300. PMID 30037300 | research article |
| 2015 | MOTS-c | Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-454. PMID: 25738459. DOI: 1… PMID 25738459 | research article |
| 2013 | MOTS-c | Lee C, Yen K, Cohen P. Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab. 2013;24(5):222-228. PMID: 23402768. PMID 23402768 | research article |
| 2020 | SLU-PP-332 | Tripathi M, Yen PM, Singh BK. Estrogen-related receptor alpha: an under-appreciated potential target for the treatment of metabolic diseases. Int J Mol Sci. 2020;21(5):1645. PMID: 32121253. PMID 32121253 | human study |
| 2025 | SLU-PP-332 | World Anti-Doping Agency. 2025 WADA Prohibited List. Section S4: Hormone and metabolic modulators. WADA, 2025. | regulatory / registry |
| 2024 | SLU-PP-332 | Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP. A synthetic ERR agonist alleviates metabolic syndrome. J Pharmacol Exp Ther. 2024;388(2):232-240. PMID: 37739806. PMID 37739806 | research article |
| 2017 | SLU-PP-332 | Fan W, Evans R. Exercise Mimetics: Impact on Health and Performance. Cell Metab. 2017;25(2):242-247. PMID: 27889389. PMID 27889389 | research article |
| 2017 | SLU-PP-332 | Misra J, Kim DK, Choi HS. ERRγ: a Junior Orphan with a Senior Role in Metabolism. Trends Endocrinol Metab. 2017;28(4):261-272. PMID: 28209382. PMID 28209382 | research article |
| 2015 | SLU-PP-332 | Huss JM, Garbacz WG, Xie W. Constitutive activities of estrogen-related receptors: Transcriptional regulation of metabolism by the ERR pathways in health and disease. Biochim Biophys Acta. 2015;1852(9):1912-1927. PMID: 26115970. PMID 26115970 | research article |
| 2013 | SLU-PP-332 | Burris TP, Solt LA, Wang Y, Crumbley C, Banerjee S, Griffett K, Lundasen T, Hughes T, Kojetin DJ. Nuclear receptors and their selective pharmacologic modulators. Pharmacol Rev. 2013;65(2):710-778. PMID: 23457206. PMID 23457206 | research article |
| 2011 | SLU-PP-332 | Narkar VA, Fan W, Downes M, Yu RT, Jonker JW, Alaynick WA, Banayo E, Karunasiri MS, Lorca S, Evans RM. Exercise and PGC-1α-independent synchronization of type I muscle metabolism and vasculature by ERRγ. Cell Metab. 2011;13(3):283-293. PMID: 21356518. PMID 21356518 | research article |
| 2010 | SLU-PP-332 | Rangwala SM, Wang X, Calvo JA, Lindsley L, Zhang Y, Deyneko G, Beaulieu V, Gao J, Turner G, Markovits J. Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity. J Biol Chem. 2010;285(29):22619-22629. PMID: 20418374. PMID 20418374 | research article |
| 2008 | SLU-PP-332 | Giguère V. Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr Rev. 2008;29(6):677-696. PMID: 18664618. PMID 18664618 | research article |
| 2008 | SLU-PP-332 | Villena JA, Kralli A. ERRalpha: a metabolic function for the oldest orphan. Trends Endocrinol Metab. 2008;19(8):269-276. PMID: 18778951. PMID 18778951 | research article |
| 2007 | SLU-PP-332 | Villena JA, Hock MB, Chang WY, Barcas JE, Giguère V, Kralli A. Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proc Natl Acad Sci USA. 2007;104(4):1418-1423. PMID: 17229846. PMID 17229846 | research article |
Related pair pages
More research context
Frequently asked
Have MOTS-c and SLU-PP-332 been studied together?
Researchers have published mechanistic-level co-administration discussion of MOTS-c and SLU-PP-332. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do MOTS-c and SLU-PP-332 share?
MOTS-c and SLU-PP-332 do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of MOTS-c and SLU-PP-332?
MOTS-c: Not approved. SLU-PP-332: Not approved (no IND). FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on MOTS-c and SLU-PP-332?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the MOTS-c profile and the SLU-PP-332 profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026