Pair page
Matrixyl with Tripeptide-29
Mechanism-tag overlap and published literature for Matrixyl and Tripeptide-29, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
collagen-signal-peptidecosmetic-peptide
cosmetic-collagen-fragment
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Matrixyl and Tripeptide-29 have published these mechanism-level observations. Not a co-administration recommendation.
The flagship matrikine peptide complex in cosmetic formulation. Matrixyl uses the palmitoylated pentapeptide-4 (pal-KTTKS) sequence — a different fragment of the type I collagen pro-peptide region — to drive a parallel matrikine signal on dermal fibroblasts. Pairing Tripeptide-29 with a Matrixyl-class peptide is the most common cosmetic formulation strategy: two complementary collagen-fragment signals at the fibroblast level. Compatible at standard formulation pH and typical use concentrations.
Quick facts
Matrixyl
Tripeptide-29
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2009 | Matrixyl | Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009;31(5):327-345. PMID: 19570099. (UCSF Dermatology systematic review of topical peptides for aged skin, including Pal-KTTKS signal-peptide class.) PMID 19570099 | systematic review |
| 2010 | Matrixyl | Fu JJ, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, Kaczvinsky JR. A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescri… PMID 20374604 | human trial |
| 2024 | Matrixyl | Vitali A, Paolicelli P, Bigi B, Trilli J, Di Muzio L, Carriero VC, Casadei MA, Petralito S. Liposome Encapsulation of the Palmitoyl-KTTKS Peptide: Structural and Functional Characterization. Pharmaceutics. 2024;16(2):219. PMID: 38399273. (Liposomal delivery system for Pal-KTTKS… PMID 38399273 | preclinical, in vitro |
| 2017 | Matrixyl | Park H, An E, Cho Lee AR. Effect of Palmitoyl-Pentapeptide (Pal-KTTKS) on Wound Contractile Process in Relation with Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression. Tissue Eng Regen Med. 2017;14(1):73-80. PMID: 30603464. (CTGF / α-SMA modulation and fibrobl… PMID 30603464 | preclinical, in vitro |
| 2014 | Matrixyl | Choi YL, Park EJ, Kim E, Na DH, Shin YH. Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS). Biomol Ther (Seoul). 2014;22(4):321-327. PMID: 25143811. (Demonstrates palmitoylation as stability and permeation enhancer relative to un… PMID 25143811 | preclinical, in vitro |
| 2013 | Matrixyl | Jones RR, Castelletto V, Connon CJ, Hamley IW. Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Mol Pharm. 2013;10(3):1063-1069. PMID: 23320752. (Direct fibroblast collagen-production dose-response for Pal-KTTKS linked to critical-aggregation-con… PMID 23320752 | preclinical, in vitro |
| 2019 | Matrixyl | Tałałaj U, Uscinowicz P, Bruzgo I, Surazynski A, Zareba I, Markowska A. The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity. Molecules. 2019;24(20):3698. PMID: 31618846. (Structure-activity series of KTTKS analogues with acetyl / lipoyl / pa… PMID 31618846 | mechanism / discovery |
| 2019 | Matrixyl | Mortazavi SM, Kobarfard F, Maibach HI, Moghimi HR. Effect of Palmitic Acid Conjugation on Physicochemical Properties of Peptide KTTKS: A Preformulation Study. J Cosmet Sci. 2019;70(6):299-312. PMID: 31829923. (Physicochemical characterization of palmitoyl conjugation effects on… PMID 31829923 | mechanism / discovery |
| 2007 | Matrixyl | Lupo MP, Cole AL. Cosmeceutical peptides. Dermatol Ther. 2007;20(5):343-349. PMID: 18045359. (Updated Dermatologic Therapy review of signal, neurotransmitter-affecting, and carrier peptides.) PMID 18045359 | review |
| 2005 | Matrixyl | Osborne R, Mullins L, Jarrold B, Lintner K. In vitro skin structure benefits with a new antiaging peptide, Pal-KT. J Am Acad Dermatol. 2005;52(3 Suppl):P34. (AAD-meeting abstract on Pal-KT / Pal-KTTKS cosmetic evaluation; Procter & Gamble / Sederma collaboration.) | industry documentation |
| 2009 | Matrixyl | Trookman NS, Rizer RL, Ford R, Ho E, Gotz V. Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles. J Clin Aesthet Dermatol. 2009;2(3):38-43. PMID: 20729942. (8-week topical treatment clinical study including palmitoyl pentapeptide active… PMID 20729942 | research article |
| 2005 | Matrixyl | Robinson LR, Fitzgerald NC, Doughty DG, Dawes NC, Berge CA, Bissett DL. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci. 2005;27(3):155-160. PMID: 18492182. (The 93-subject 12-week split-face vehicle-controlled RCT of 3 ppm Pa… PMID 18492182 | research article |
| 2019 | Tripeptide-29 | Choi FD, Sung CT, Juhasz ML, Mesinkovsk NA. Oral Collagen Supplementation: A Systematic Review of Dermatological Applications. J Drugs Dermatol. 2019;18(1):9-16. PMID: 30681787. (Systematic review of 11 RCTs of oral collagen supplementation, 805 patients; includes 2 collagen tri… PMID 30681787 | systematic review |
| 2022 | Tripeptide-29 | Kim J, Lee SG, Lee J, Choi S, Suk J, Lee JH, Yang JH, Yang JS, Kim J. Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study. J Med Food. 2022;25(12)… PMID 36516059 | human trial |
| 2019 | Tripeptide-29 | Bolke L, Schlippe G, Gerß J, Voss W. A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients. 2019;11(10):2494. PMID: 31627309. doi: 10.3390/nu11102494. (Multi-ingredient nutricosmetic… PMID 31627309 | human trial |
| 2018 | Tripeptide-29 | Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018;10(7):826. doi: 10.3390/nu10070826. (Oral LMWCP prep… | human trial |
| 2015 | Tripeptide-29 | Asserin J, Lati E, Shioya T, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015;14(4):291-301. PMID: 26362110.… PMID 26362110 | human trial |
| 2014 | Tripeptide-29 | Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. PMID: 23949208. doi: 10.1159/0003… PMID 23949208 | human trial |
| 2022 | Tripeptide-29 | Taga Y, Iwasaki Y, Shigemura Y, Mizuno K. Identification of a Highly Stable Bioactive 3-Hydroxyproline-Containing Tripeptide in Human Blood after Collagen Hydrolysate Ingestion. npj Sci Food. 2022;6(1):29. (Identification of Gly-3Hyp-4Hyp as a stable bioactive collagen tripeptid… | human study |
| 2017 | Tripeptide-29 | Hexsel D, Zague V, Schunck M, Siega C, Camargo FB Jr, Oesser S. Oral supplementation of specific bioactive collagen peptides reduces skin wrinkles and improves nail growth in women. J Cosmet Dermatol. 2017;16(4):520-526. PMID: 28786550. (Oral bioactive collagen peptides RCT in n… PMID 28786550 | human study |
| 2005 | Tripeptide-29 | Iwai K, Hasegawa T, Taguchi Y, Morimatsu F, Sato K, Nakamura Y, Higashi A, Kido Y, Nakabo Y, Ohtsuki K. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem. 2005;53(16):6531-6536. PMID: 16076145. doi: 10… PMID 16076145 | human study |
| 2020 | Tripeptide-29 | Asai TT, Yoshikawa K, Sawada K, Fukamizu K, Koyama YI, Shigemura Y, Jimi S, Sato K. Mouse skin fibroblasts with mesenchymal stem cell marker p75 neurotrophin receptor proliferate in response to prolyl-hydroxyproline. J Funct Foods. 2020;66:103792. (p75NTR-positive fibroblast sub… | preclinical, in vivo |
| 2019 | Tripeptide-29 | Asai TT, Oikawa F, Yoshikawa K, Inoue N, Sato K. Food-Derived Collagen Peptides, Prolyl-Hydroxyproline (Pro-Hyp), and Hydroxyprolyl-Glycine (Hyp-Gly) Enhance Growth of Primary Cultured Mouse Skin Fibroblast Using Fetal Bovine Serum Free from Hydroxyprolyl Peptide. Int J Mol Sci.… | preclinical, in vivo |
| 2016 | Tripeptide-29 | Sontakke SB, Jung JH, Piao Z, Chung HJ. Orally Available Collagen Tripeptide: Enzymatic Stability, Intestinal Permeability, and Absorption of Gly-Pro-Hyp and Pro-Hyp. J Agric Food Chem. 2016;64(38):7127-7133. PMID: 27573716. (Differential bioavailability of GPH vs Pro-Hyp; biotr… PMID 27573716 | preclinical, in vivo |
Related pair pages
More research context
Frequently asked
Have Matrixyl and Tripeptide-29 been studied together?
Researchers have published mechanistic-level co-administration discussion of Matrixyl and Tripeptide-29. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Matrixyl and Tripeptide-29 share?
Matrixyl and Tripeptide-29 do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Matrixyl and Tripeptide-29?
Matrixyl: Cosmetic ingredient (not a drug). Tripeptide-29: Cosmetic ingredient (no premarket approval). FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Matrixyl and Tripeptide-29?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Matrixyl profile and the Tripeptide-29 profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026