Pair page
Matrixyl with Rigin
Mechanism-tag overlap and published literature for Matrixyl and Rigin, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
collagen-signal-peptidecosmetic-peptide
cosmetic-immune-modulating-tetrapeptide
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Matrixyl and Rigin have published these mechanism-level observations. Not a co-administration recommendation.
The canonical pairing. Palmitoyl tripeptide-1 (pal-GHK) combined with palmitoyl tetrapeptide-7 (pal-GQPR) is the Sederma Matrixyl 3000 combination, positioned as complementary synthesis (palmitoyl tripeptide-1) and anti-degradation (Rigin) signals. Matrixyl (palmitoyl pentapeptide-4) is a related Sederma signal peptide often used alongside Rigin in combination anti-aging formulas.
Quick facts
Matrixyl
Rigin
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2009 | Matrixyl | Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009;31(5):327-345. PMID: 19570099. (UCSF Dermatology systematic review of topical peptides for aged skin, including Pal-KTTKS signal-peptide class.) PMID 19570099 | systematic review |
| 2010 | Matrixyl | Fu JJ, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, Kaczvinsky JR. A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescri… PMID 20374604 | human trial |
| 2024 | Matrixyl | Vitali A, Paolicelli P, Bigi B, Trilli J, Di Muzio L, Carriero VC, Casadei MA, Petralito S. Liposome Encapsulation of the Palmitoyl-KTTKS Peptide: Structural and Functional Characterization. Pharmaceutics. 2024;16(2):219. PMID: 38399273. (Liposomal delivery system for Pal-KTTKS… PMID 38399273 | preclinical, in vitro |
| 2017 | Matrixyl | Park H, An E, Cho Lee AR. Effect of Palmitoyl-Pentapeptide (Pal-KTTKS) on Wound Contractile Process in Relation with Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression. Tissue Eng Regen Med. 2017;14(1):73-80. PMID: 30603464. (CTGF / α-SMA modulation and fibrobl… PMID 30603464 | preclinical, in vitro |
| 2014 | Matrixyl | Choi YL, Park EJ, Kim E, Na DH, Shin YH. Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS). Biomol Ther (Seoul). 2014;22(4):321-327. PMID: 25143811. (Demonstrates palmitoylation as stability and permeation enhancer relative to un… PMID 25143811 | preclinical, in vitro |
| 2013 | Matrixyl | Jones RR, Castelletto V, Connon CJ, Hamley IW. Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Mol Pharm. 2013;10(3):1063-1069. PMID: 23320752. (Direct fibroblast collagen-production dose-response for Pal-KTTKS linked to critical-aggregation-con… PMID 23320752 | preclinical, in vitro |
| 2019 | Matrixyl | Tałałaj U, Uscinowicz P, Bruzgo I, Surazynski A, Zareba I, Markowska A. The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity. Molecules. 2019;24(20):3698. PMID: 31618846. (Structure-activity series of KTTKS analogues with acetyl / lipoyl / pa… PMID 31618846 | mechanism / discovery |
| 2019 | Matrixyl | Mortazavi SM, Kobarfard F, Maibach HI, Moghimi HR. Effect of Palmitic Acid Conjugation on Physicochemical Properties of Peptide KTTKS: A Preformulation Study. J Cosmet Sci. 2019;70(6):299-312. PMID: 31829923. (Physicochemical characterization of palmitoyl conjugation effects on… PMID 31829923 | mechanism / discovery |
| 2007 | Matrixyl | Lupo MP, Cole AL. Cosmeceutical peptides. Dermatol Ther. 2007;20(5):343-349. PMID: 18045359. (Updated Dermatologic Therapy review of signal, neurotransmitter-affecting, and carrier peptides.) PMID 18045359 | review |
| 2005 | Matrixyl | Osborne R, Mullins L, Jarrold B, Lintner K. In vitro skin structure benefits with a new antiaging peptide, Pal-KT. J Am Acad Dermatol. 2005;52(3 Suppl):P34. (AAD-meeting abstract on Pal-KT / Pal-KTTKS cosmetic evaluation; Procter & Gamble / Sederma collaboration.) | industry documentation |
| 2009 | Matrixyl | Trookman NS, Rizer RL, Ford R, Ho E, Gotz V. Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles. J Clin Aesthet Dermatol. 2009;2(3):38-43. PMID: 20729942. (8-week topical treatment clinical study including palmitoyl pentapeptide active… PMID 20729942 | research article |
| 2005 | Matrixyl | Robinson LR, Fitzgerald NC, Doughty DG, Dawes NC, Berge CA, Bissett DL. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci. 2005;27(3):155-160. PMID: 18492182. (The 93-subject 12-week split-face vehicle-controlled RCT of 3 ppm Pa… PMID 18492182 | research article |
| 2002 | Rigin | Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. PMID: 18498523. (Foundational cosmetic peptide characte… PMID 18498523 | mechanism / discovery |
| 2021 | Rigin | Ferreira MSM, Sousa Lobo JM, Almeida IF. Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel). 2021;14(8):702. PMID: 34358128. (Review of cosmetic peptide use in sensitive-skin formulations, with mechanistic discussion of palmitoyl tetrapeptide-7'… PMID 34358128 | review |
| 2020 | Rigin | Ferreira MS, Magalhães MC, Sousa Lobo JM, Almeida IF. Trending Anti-Aging Peptides. Cosmetics. 2020;7(4):91. doi:10.3390/cosmetics7040091. (Review of the current cosmetic peptide landscape with detailed discussion of palmitoyl tetrapeptide-7 mechanism claims.) | review |
| 2012 | Rigin | Reddy BY, Jow T, Hantash BM. Bioactive oligopeptides in dermatology: Part I. Exp Dermatol. 2012;21(8):563-568. PMID: 22672785. (Review of bioactive oligopeptides in dermatology including cosmetic palmitoyl-conjugate peptides.) PMID 22672785 | review |
| 2009 | Rigin | Zhang L, Falla TJ. Cosmeceuticals and peptides. Clin Dermatol. 2009;27(5):485-494. PMID: 19695480. (Cosmeceutical peptide review discussing palmitoyl tetrapeptide-7 positioning within the signal / neurotransmitter / carrier peptide framework.) PMID 19695480 | review |
| 2006 | Rigin | Maggio M, Guralnik JM, Longo DL, Ferrucci L. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci. 2006;61(6):575-584. PMID: 16799139. (Foundational review of IL-6 in aging — the biological plausibility case for Rigin's anti-inflammagi… PMID 16799139 | review |
| 1987 | Rigin | Rocchi R, Biondi L, Filira F, Gobbo M, Dagan S, Fridkin M. Synthesis and biological activity of tuftsin and rigin derivatives containing monosaccharides or monosaccharide derivatives. Int J Pept Protein Res. 1987;29(2):250-261. PMID: 3570655. (Classic synthesis and biological ch… PMID 3570655 | industry documentation |
| 2020 | Rigin | Errante F, Ledwoń P, Latajka R, Rovero P, Papini AM. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020;8:572923. PMID: 33195067. (Cosmetic peptide overview referencing palmitoyl tetrapeptide-7 within the broader framework of synthetic cosm… PMID 33195067 | research article |
| 2018 | Rigin | Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14(10):576-590. PMID: 30046148. (Inflammaging framework citation — the broader biological context for cosmetic anti-infla… PMID 30046148 | research article |
| 2015 | Rigin | Hoppel M, Reznicek G, Kählig H, Kotisch H, Resch GP, Valenta C. Topical delivery of acetyl hexapeptide-8 from different emulsions: Influence of emulsion composition and internal structure. Eur J Pharm Sci. 2015;68:27-35. PMID: 25433250. (Methodologically adjacent cosmetic peptid… PMID 25433250 | research article |
| 2009 | Rigin | Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009;31(5):327-345. PMID: 19570043. (Cosmetic peptide topical-delivery review — stratum corneum penetration, palmitoyl conjugate strategy, and mechanism-by-mechanism evidence i… PMID 19570043 | research article |
| 2009 | Rigin | Fields K, Falla TJ, Rodan K, Bush L. Bioactive peptides: signaling the future. J Cosmet Dermatol. 2009;8(1):8-13. PMID: 19250160. (Cosmetic bioactive peptide overview covering palmitoyl tetrapeptide-7 class and combination formulation logic.) PMID 19250160 | research article |
Related pair pages
More research context
Frequently asked
Have Matrixyl and Rigin been studied together?
Researchers have published mechanistic-level co-administration discussion of Matrixyl and Rigin. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Matrixyl and Rigin share?
Matrixyl and Rigin do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Matrixyl and Rigin?
Matrixyl: Cosmetic ingredient (not a drug). Rigin: Cosmetic ingredient. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Matrixyl and Rigin?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Matrixyl profile and the Rigin profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026