Pair page
Epithalon with Vesugen
Mechanism-tag overlap and published literature for Epithalon and Vesugen, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
pineal-tetrapeptide-khavinson-bioregulator
khavinson-short-peptide-bioregulatorvascular
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Epithalon and Vesugen have published these mechanism-level observations. Not a co-administration recommendation.
Pineal-gland Khavinson peptide targeting telomere maintenance and circadian rhythm. Frequently layered in cyclical Khavinson "longevity" protocols alongside Vesugen.
Quick facts
Epithalon
Vesugen
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2010 | Epithalon | Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector Epitalamin: effects on vascular endothelial function in elderly patients. Adv Gerontol. 2010;23(3):440-446. | human study |
| 2004 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004;137(5):503-506. | human study |
| 2003 | Epithalon | Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. PMID: 14523363. (266-patient elderly mortality cohort.) PMID 14523363 | human study |
| 2021 | Epithalon | Khavinson V, Ilina A, Kraskovskaya N, Linkova N, Kolchina N, Mikhailova N, Petukhov M. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel). 2021;14(6):515. | preclinical, in vivo |
| 2004 | Epithalon | Labunets IF, Butenko GM, Dragunova VA, Magdich LV, Khavinson VKh. Effect of epithalamin, thymalin, and tocopherol on age-associated involution of the pineal gland in rats. Bull Exp Biol Med. 2004;137(5):510-512. | preclinical, in vivo |
| 2003 | Epithalon | Anisimov VN, Khavinson VKh, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4)… PMID 14501183 | preclinical, in vivo |
| 2003 | Epithalon | Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. Int J Mol Med. 2003;12(4):473-477. PMID: 12964019. PMID 12964019 | preclinical, in vivo |
| 2025 | Epithalon | Al-Dulaimi MS, et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. 2025. PMID: 40908429. PMC12411320. (Modern Western-lab replication of the central telomerase-activation claim.) PMID 40908429 | mechanism / discovery |
| 2017 | Epithalon | Khavinson V, Popovich I. Short peptides regulate gene expression, protein synthesis and enhance life span. In: Understanding the Aging Process and Age-Related Diseases. Academic Press; 2017. | mechanism / discovery |
| 2016 | Epithalon | Khavinson VKh, Linkova NS, Tarnovskaia SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288-292. | mechanism / discovery |
| 2003 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bull Exp Biol Med. 2003;135(6):590-592. PMID: 12937682. PMID 12937682 | mechanism / discovery |
| 2017 | Epithalon | Khavinson VKh, Kopylov AT, Vaskovsky BV, Ryzhak GA, Lin'kova NS. Identification of peptide AEDG in the polypeptide complex of the pineal gland. Bull Exp Biol Med. 2017;164(1):41-43. | bioregulator literature |
| 2021 | Vesugen | Khavinson VKh, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide regulation of gene expression: a systematic review. Molecules. 2021;26(22):7053. PMID: 34834146. PMID 34834146 | systematic review |
| 2016 | Vesugen | Linkova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, Khavinson VKh. Peptide regulation of skin fibroblast functions during their aging in vitro. Bull Exp Biol Med. 2016;161(1):175-178. PMID: 27265131. PMID 27265131 | preclinical, in vitro |
| 2016 | Vesugen | Khavinson VKh, Linkova NS, Tarnovskaya SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288-292. PMID: 27905024. PMID 27905024 | mechanism / discovery |
| 2014 | Vesugen | Khavinson VKh, Tendler SM, Vanyushin BF, Kasyanenko NA, Kvetnoy IM, Linkova NS, et al. Peptide regulation of gene expression and protein synthesis in bronchial epithelium. Lung. 2014;192(5):781-791. PMID: 24920421. PMID 24920421 | mechanism / discovery |
| 2025 | Vesugen | World Anti-Doping Agency. 2025 WADA Prohibited List. WADA, 2025. | regulatory / registry |
| 2022 | Vesugen | Khavinson V, Linkova N, Umnov R. Peptide KED: biological activity and mechanisms of action. Int J Mol Sci. 2022;23(2):852. (KED sequence biology review.) | bioregulator literature |
| 2013 | Vesugen | Khavinson VKh, Kuznik BI, Ryzhak GA. Peptide bioregulators: a new class of geroprotectors. Report 1. Adv Gerontol. 2013;3(2):83-93. | bioregulator literature |
| 2013 | Vesugen | Linkova NS, Kuznik BI, Khavinson VKh. Peptide bioregulators in vascular aging. Advances in Gerontology. 2013;3(4):267-273. | bioregulator literature |
| 2012 | Vesugen | Kuznik BI, Khavinson VKh, Linkova NS. Heat shock proteins, peptide bioregulators, and aging. Adv Gerontol. 2012;25(3):371-380. | bioregulator literature |
| 2010 | Vesugen | Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149. PMID: 19609712. PMID 19609712 | bioregulator literature |
| 2005 | Vesugen | Khavinson VKh, Malinin VV. Gerontological Aspects of Genome Peptide Regulation. Karger, Basel, 2005. | bioregulator literature |
| 2002 | Vesugen | Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144. PMID: 12373186. PMID 12373186 | bioregulator literature |
Related pair pages
More research context
Frequently asked
Have Epithalon and Vesugen been studied together?
Researchers have published mechanistic-level co-administration discussion of Epithalon and Vesugen. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Epithalon and Vesugen share?
Epithalon and Vesugen do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Epithalon and Vesugen?
Epithalon: Not approved. Vesugen: Not approved. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Epithalon and Vesugen?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Epithalon profile and the Vesugen profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026