Pair page
Epithalon with Testagen
Mechanism-tag overlap and published literature for Epithalon and Testagen, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
pineal-tetrapeptide-khavinson-bioregulator
khavinson-testicular-bioregulator
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Epithalon and Testagen have published these mechanism-level observations. Not a co-administration recommendation.
Khavinson pineal tetrapeptide (Ala-Glu-Asp-Gly; AEDG). Commonly paired with Testagen as part of the broader Khavinson "bioregulator protocol" covering pineal/circadian-aging (Epithalon) alongside testicular-aging (Testagen). Mechanistic independence; additive in the Khavinson framework.
Quick facts
Epithalon
Testagen
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2010 | Epithalon | Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector Epitalamin: effects on vascular endothelial function in elderly patients. Adv Gerontol. 2010;23(3):440-446. | human study |
| 2004 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004;137(5):503-506. | human study |
| 2003 | Epithalon | Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. PMID: 14523363. (266-patient elderly mortality cohort.) PMID 14523363 | human study |
| 2021 | Epithalon | Khavinson V, Ilina A, Kraskovskaya N, Linkova N, Kolchina N, Mikhailova N, Petukhov M. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel). 2021;14(6):515. | preclinical, in vivo |
| 2004 | Epithalon | Labunets IF, Butenko GM, Dragunova VA, Magdich LV, Khavinson VKh. Effect of epithalamin, thymalin, and tocopherol on age-associated involution of the pineal gland in rats. Bull Exp Biol Med. 2004;137(5):510-512. | preclinical, in vivo |
| 2003 | Epithalon | Anisimov VN, Khavinson VKh, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4)… PMID 14501183 | preclinical, in vivo |
| 2003 | Epithalon | Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. Int J Mol Med. 2003;12(4):473-477. PMID: 12964019. PMID 12964019 | preclinical, in vivo |
| 2025 | Epithalon | Al-Dulaimi MS, et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. 2025. PMID: 40908429. PMC12411320. (Modern Western-lab replication of the central telomerase-activation claim.) PMID 40908429 | mechanism / discovery |
| 2017 | Epithalon | Khavinson V, Popovich I. Short peptides regulate gene expression, protein synthesis and enhance life span. In: Understanding the Aging Process and Age-Related Diseases. Academic Press; 2017. | mechanism / discovery |
| 2016 | Epithalon | Khavinson VKh, Linkova NS, Tarnovskaia SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288-292. | mechanism / discovery |
| 2003 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bull Exp Biol Med. 2003;135(6):590-592. PMID: 12937682. PMID 12937682 | mechanism / discovery |
| 2017 | Epithalon | Khavinson VKh, Kopylov AT, Vaskovsky BV, Ryzhak GA, Lin'kova NS. Identification of peptide AEDG in the polypeptide complex of the pineal gland. Bull Exp Biol Med. 2017;164(1):41-43. | bioregulator literature |
| 2012 | Testagen | Khavinson VK, Solovyev AY, Zhilinskiy DV, Shataeva LK, Vanyushin BF. Effect of peptides on the proliferative activity of cells of rat pituitary anterior lobe in organotypic culture. Bull Exp Biol Med. 2012;153(1):148-151. PMID: 22808512. PMID 22808512 | preclinical, in vivo |
| 2011 | Testagen | Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011;76(11):1210-1219. PMID: 221… PMID 22118470 | preclinical, in vitro |
| 2021 | Testagen | Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide regulation of cell differentiation, gene expression, and protein synthesis. Bull Exp Biol Med. 2021;170(5):707-711. (Review including testicular and other tissue-specific peptides.) | mechanism / discovery |
| 2003 | Testagen | Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. PMID: 12937678. (Representative Khavinson-group mechanistic paper; establishes the methodological style.) PMID 12937678 | mechanism / discovery |
| 2002 | Testagen | Khavinson VK. Peptides and Ageing. Neuroendocrinol Lett. 2002;23 Suppl 3:11-144. PMID: 12374906. (Foundational review of the Khavinson peptide bioregulator framework.) PMID 12374906 | review |
| 2026 | Testagen | ClinicalTrials.gov. Search: "Testagen" or "KEDG peptide" returns no registered trials. Accessed April 2026. | regulatory / registry |
| 2025 | Testagen | FDA. Bulk Drug Substances Nominated for Use in Compounding under Section 503A of the Federal Food, Drug, and Cosmetic Act. FDA.gov. Updated 2025–2026 (Testagen / KEDG not listed). | regulatory / registry |
| 2025 | Testagen | WADA. 2025 Prohibited List. World Anti-Doping Agency. (Testagen not specifically named.) | regulatory / registry |
| 2020 | Testagen | Khavinson VK, Linkova NS, Ashapkin VV, Ryzhak GA. Peptide Regulation of Aging: 40 Years of Research. Bull Exp Biol Med. 2020;170(2):190-193. PMID: 33263832. PMID 33263832 | bioregulator literature |
| 2020 | Testagen | Khavinson VK. Peptide drugs: their role in fundamental and applied medicine. Advances in Gerontology. 2020 Khavinson group series. | bioregulator literature |
| 2011 | Testagen | Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: results of 15-year follow-up study. Bull Exp Biol Med. 2011;151(3):366-369. PMID: 22451891. PMID 22451891 | bioregulator literature |
| 2010 | Testagen | Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149. PMID: 19415510. PMID 19415510 | bioregulator literature |
Related pair pages
More research context
Frequently asked
Have Epithalon and Testagen been studied together?
Researchers have published mechanistic-level co-administration discussion of Epithalon and Testagen. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Epithalon and Testagen share?
Epithalon and Testagen do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Epithalon and Testagen?
Epithalon: Not approved. Testagen: Not approved; research-only. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Epithalon and Testagen?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Epithalon profile and the Testagen profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026