Pair page
Cerebrolysin with N-Acetyl-Epithalon
Mechanism-tag overlap and published literature for Cerebrolysin and N-Acetyl-Epithalon, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
neurotrophic-brain-bioregulator
modified-pineal-bioregulator-tetrapeptide
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Cerebrolysin and N-Acetyl-Epithalon have published these mechanism-level observations. Not a co-administration recommendation.
Porcine brain peptide hydrolysate (Ever Neuro Pharma) with neurotrophic / neuroprotective signaling. Sometimes paired in cognitive-aging stacks where N-Acetyl-Epithalon provides the pineal / telomere-axis component and Cerebrolysin provides the brain-trophic component. Mechanistically distinct, no known pharmacokinetic conflict.
Quick facts
Cerebrolysin
N-Acetyl-Epithalon
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2021 | Cerebrolysin | Vester JC, Buzoianu AD, Florian SI, Hömberg V, Kim SH, Lee TMC, Matula C, Poon WS, von Steinbüchel N, Strilciuc S, von Wild K, Muresanu D. Cerebrolysin after moderate to severe traumatic brain injury: prospective meta-analysis of the CAPTAIN trial series. Neurol Sci. 2021;42(2):… PMID 33620612 | meta-analysis |
| 2018 | Cerebrolysin | Bornstein NM, Guekht A, Vester J, Heiss WD, Gusev E, Hömberg V, Rahlfs VW, Bajenaru O, Popescu BO, Muresanu D. Safety and efficacy of Cerebrolysin in early post-stroke recovery: a meta-analysis of nine randomized clinical trials. Neurol Sci. 2018;39(4):629-640. PMID: 29248999. PMID 29248999 | meta-analysis |
| 2015 | Cerebrolysin | Gauthier S, Proaño JV, Jia J, Froelich L, Vester JC, Doppler E. Cerebrolysin in mild-to-moderate Alzheimer's disease: a meta-analysis of randomized controlled clinical trials. Dement Geriatr Cogn Disord. 2015;39(5-6):332-347. PMID: 25832905. PMID 25832905 | meta-analysis |
| 2020 | Cerebrolysin | Poon W, Vos P, Muresanu D, Vester J, von Wild K, Hömberg V, et al. Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I — a randomized, placebo-controlled, double-blind, Asian-Pacific trial. Neurol Sci. 2020;41(2):281-293. PMID: 31494820. PMID 31494820 | human trial |
| 2020 | Cerebrolysin | Woo PYM, Ho JWK, Ko NMW, Li RPT, Jian L, Chu ACH, Kwan MCL, Chan Y, Wong AKS, Wong HT, Chan KY, Kwok JCK. Randomized, placebo-controlled, double-blind, pilot trial to investigate safety and efficacy of Cerebrolysin in patients with aneurysmal subarachnoid hemorrhage. BMC Neurol.… PMID 33143640 | human trial |
| 2017 | Cerebrolysin | Gharagozli K, Harandi AA, Houshmand S, Akbari N, Muresanu DF, Vester J, Winter S, Moessler H. Efficacy and safety of Cerebrolysin treatment in early recovery after acute ischemic stroke: a randomized, placebo-controlled, double-blinded, multicenter clinical trial. J Med Life. 20… PMID 29075343 | human trial |
| 2016 | Cerebrolysin | Muresanu DF, Heiss WD, Hoemberg V, Bajenaru O, Popescu CD, Vester JC, Rahlfs VW, Doppler E, Meier D, Moessler H, Guekht A. Cerebrolysin and Recovery After Stroke (CARS): A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial. Stroke. 2016;47(1):151-159. PMID: 26564102. PMID 26564102 | human trial |
| 2016 | Cerebrolysin | Hassanein SM, Deifalla SM, El-Houssinie M, Mokbel SA. Safety and Efficacy of Cerebrolysin in Infants with Communication Defects due to Severe Perinatal Brain Insult: A Randomized Controlled Clinical Trial. J Clin Neurol. 2016;12(1):79-84. PMID: 26365023. PMID 26365023 | human trial |
| 2012 | Cerebrolysin | Heiss WD, Brainin M, Bornstein NM, Tuomilehto J, Hong Z; Cerebrolysin Acute Stroke Treatment in Asia (CASTA) Investigators. Cerebrolysin in patients with acute ischemic stroke in Asia: results of a double-blind, placebo-controlled randomized trial. Stroke. 2012;43(3):630-636. PM… PMID 22282884 | human trial |
| 2010 | Cerebrolysin | Heiss WD, Brainin M, Bornstein NM, Tuomilehto J, Hong Z. A double-blind, placebo-controlled, randomized trial to evaluate the safety and efficacy of Cerebrolysin in patients with acute ischaemic stroke in Asia — CASTA. Int J Stroke. 2010;5(4):310-313. PMID: 19765131. PMID 19765131 | human trial |
| 2005 | Cerebrolysin | Ladurner G, Kalvach P, Moessler H; Cerebrolysin Study Group. Neuroprotective treatment with cerebrolysin in patients with acute stroke: a randomised controlled trial. J Neural Transm (Vienna). 2005;112(3):415-428. PMID: 15583955. PMID 15583955 | human trial |
| 2023 | Cerebrolysin | Rejdak K, Sienkiewicz-Jarosz H, Bienkowski P, Alvarez A. Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin. Med Res Rev. 2023;43(5):1668-1700. PMID: 37052231. PMID 37052231 | human study |
| 2020 | N-Acetyl-Epithalon | Khavinson V, Linkova N, Dyatlova A, Kuznik B, Umnov R. Peptides: Prospects for Use in the Treatment of COVID-19. Molecules. 2020;25(19):4389. (Khavinson-group review of short peptide bioregulator applications including AEDG / Epitalon mechanistic discussion.) | human study |
| 2011 | N-Acetyl-Epithalon | Korkushko OV, Khavinson VK, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: results of 15-year follow-up. Bull Exp Biol Med. 2011;151(3):366-369. (Long-term follow-up extension of the Korkushko/Khavinson eld… | human study |
| 2003 | N-Acetyl-Epithalon | Khavinson VK, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. PMID: 14523363. (Khavinson-group review of the 266-subject elderly cohort treated with Thymalin and Epithalamin over 6–8 years; reported mortality reduc… PMID 14523363 | human study |
| 2007 | N-Acetyl-Epithalon | Kozina LS, Arutjunyan AV, Khavinson VK. Antioxidant properties of geroprotective peptides of the pineal gland. Arch Gerontol Geriatr. 2007;44 Suppl 1:213-216. PMID: 17317455. (Pineal peptide preparations including Epitalon possess antioxidant properties exceeding melatonin's in… PMID 17317455 | preclinical, in vivo |
| 2003 | N-Acetyl-Epithalon | Anisimov VN, Khavinson VK, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. (1… | preclinical, in vivo |
| 2002 | N-Acetyl-Epithalon | Anisimov VN, Khavinson VK, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer. 2002;101(1… PMID 12209581 | preclinical, in vivo |
| 2002 | N-Acetyl-Epithalon | Anisimov SV, Bokeler KR, Khavinson VK, Anisimov VN. Studies of the effects of Vilon and Epitalon on gene expression in mouse heart using DNA microarray technology. Bull Exp Biol Med. 2002;133(3):293-299. (DNA microarray analysis of AEDG peptide effects on mouse cardiac gene expr… | preclinical, in vivo |
| 2001 | N-Acetyl-Epithalon | Anisimov VN, Khavinson VK, Mikhalski AI, Yashin AI. Effect of synthetic dipeptide Vilon (Lys-Glu) on gene expression in mice. Mech Ageing Dev. 2001;122(13):1297-1304. (Sister Khavinson short-peptide dipeptide; gene-expression effects in mice — supports the transcription-modulati… | preclinical, in vivo |
| 2011 | N-Acetyl-Epithalon | Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011;76(11):1210-1219. PMID: 221… PMID 22117545 | preclinical, in vitro |
| 2004 | N-Acetyl-Epithalon | Khavinson VK, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004;137(5):503-506. (Parent Epithalon extension of fibroblast replicative capacity beyond the Hayflick limit.) | preclinical, in vitro |
| 2003 | N-Acetyl-Epithalon | Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. PMID: 12937682. (The seminal in-vitro telomerase induction finding for parent Epithalon — fetal fibroblas… PMID 12937682 | preclinical, in vitro |
| 2025 | N-Acetyl-Epithalon | Araj S, et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. (2025). Independent replication of the core telomere-lengthening claim in modern human cell lines, with the mechanistic nuance that ALT pathway activation is ob… | mechanism / discovery |
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Frequently asked
Have Cerebrolysin and N-Acetyl-Epithalon been studied together?
Researchers have published mechanistic-level co-administration discussion of Cerebrolysin and N-Acetyl-Epithalon. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Cerebrolysin and N-Acetyl-Epithalon share?
Cerebrolysin and N-Acetyl-Epithalon do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Cerebrolysin and N-Acetyl-Epithalon?
Cerebrolysin: Not approved (US). N-Acetyl-Epithalon: Not approved — research only. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Cerebrolysin and N-Acetyl-Epithalon?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Cerebrolysin profile and the N-Acetyl-Epithalon profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026