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Stack — Sleep & focus

Flow State Stack — Selank + Semax + Epitalon · Tested together in people: none published

Gray market

Checked · 22 sources · 9 corrections on this page · No vendors · No affiliates · No one buys a word of it

Selank: no FDA ruling — not on any list

Sold as a research chemical. Some clinics and pharmacies still supply it; that’s their risk, not a change in the rule.

Built on: Cognitive & Sleep Architecture

The receipt

0 studies gave them to people together

Evidence on the combination
No data

None published

No study that gave them to people together is among the sources Kalios cites. Reports of people already taking both, registered trials, conference talks, patents and makers’ own tests don’t count.

What each does alone

Mechanism overlap · reasoning, not evidence

Selank
Peptide — Anxiolytic Nootropic (Tuftsin Analog)
Semax
Peptide — Nootropic & Neuroprotective (ACTH Analog)
Epithalon
Peptide — Pineal Tetrapeptide / Khavinson Bioregulator

Reasoning, not evidence: what each is described to do says nothing about what they do together.

References

No clinical trial has studied the Selank + Semax + Epitalon combination in humans. The references below are for the individual components and their mechanistic framework.

  1. Zozulia AA, Neznamov GG, Syunyakov TS, et al. [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48. PMID: 18454096. (Russian Phase 3 pivotal trial vs medazepam.)
  2. Volkova A, Shadrina M, Kolomin T, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31. PMID: 26924987. PMC4757669.
  3. Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD. Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bull Exp Biol Med. 2019;167(5):641-644. PMID: 31625062.
  4. Gusev EI, Skvortsova VI, Miasoedov NF, et al. [Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)]. Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(6):26-34. PMID: 11517472.
  5. Dolotov OV, Karpenko EA, Inozemtseva LS, et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. J Neurochem. 2006;97 Suppl 1:82-86. PMID: 16635254.
  6. Dolotov OV, Karpenko EA, Inozemtseva LS, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006;1117(1):54-60. PMID: 16996037.
  7. Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bull Exp Biol Med. 2003;135(6):590-592. PMID: 12937682.
  8. Al-Dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025;26(5):178. PMID: 40908429. PMC12411320. (Erratum: Biogerontology. 2025;27(1):1.)
  9. Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. PMID: 14523363.
  10. Kost NV, Sokolov OY, Gabaeva MV, et al. [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]. Bioorg Khim. 2001;27(3):180-183. PMID: 11443939.
  11. Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA, Shcherbenko VE, Mezentseva MV, Gabaeva MV, Sokolov OIu, Zozulia AA, Ershov FI. Immunomodulatory effects of selank in patients with anxiety-asthenic disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-75. PMID: 18577961.
  12. Shadrina MI, Dolotov OV, Grivennikov IA, Slominsky PA, Andreeva LA, Inozemtseva LS, Limborska SA, Myasoedov NF. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001;308(2):115-118. PMID: 11457573.
  13. Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005;30(12):1493-1500. PMID: 16362768.
  14. Korkushko OV, Lapin BA, Goncharova ND, Khavinson VKh, Shatilo VB, Vengerin AA, Antoniuk-Shcheglova IA, Magdich LV. Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people. Adv Gerontol. 2007;20(1):74-85. PMID: 17969590.
  15. Anisimov VN, Mylnikov SV, Khavinson VK. Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats. Mech Ageing Dev. 1998;103(2):123-132. PMID: 9701766.
  16. Anisimov VN, Popovich IG, Zabezhinskii MA, Rozenfel'd SV, Khavinson VKh, Semenchenko AV, Iashin AI. Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM). Vopr Onkol. 2005;51(1):93-98. PMID: 15909815.
  17. FDA. Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the FD&C Act (503A categories list), versions updated April 15, April 22 and May 14, 2026. fda.gov/media/94155/download. Read October 3, 2026. (Notice that 12 peptides would leave Category 2 because their nominations were withdrawn; their removal; GHK-Cu, except injectable, back in Category 1.)
  18. RLS (Register of Medicines of Russia, an online drug-reference publication). Селанк® (Selank) 0.15% nasal drops: instructions for medical use, registration ЛП-№(010951)-(РГ-RU), last changed July 15, 2025; holder and maker АО «ИНПЦ «Пептоген», Moscow; dispensed without a prescription. rlsnet.ru/drugs/selank-36612. Page updated April 8, 2026. Read October 23, 2026. In Russian. (Indications, dose and course, contraindications, side effects, interactions, nasal absorption, storage.)
  19. RLS (Register of Medicines of Russia, an online drug-reference publication). Семакс® (Semax) 0.1% and 1% nasal drops: descriptions approved by the maker in 2008 (agreed August 9, 2008), based on the official instructions; RLS marks both “dispensed by prescription” and as on Russia’s list of vital and essential medicines. rlsnet.ru/drugs/semaks-5420. Page updated May 15, 2026. Read October 23, 2026. In Russian. (Composition, pharmacokinetics, indications, contraindications, doses and course, side effects, storage.)
  20. FDA. Evaluation of Semax-Related Bulk Drug Substances (Semax (Free Base) and Semax Acetate) for Inclusion on the 503A Bulk Drug Substances List. FDA Briefing Document, Pharmacy Compounding Advisory Committee meeting of July 23–24, 2026 (memorandum dated May 11, 2026). fda.gov/media/193348/download. Read October 3, 2026.
  21. FDA. Evaluation of Epitalon-Related Bulk Drug Substances (Epitalon (Free Base) and Epitalon Acetate) for Inclusion on the 503A Bulk Drug Substances List. FDA Briefing Document, Pharmacy Compounding Advisory Committee meeting of July 23–24, 2026 (memorandum dated May 12, 2026). fda.gov/media/193345/download. Read October 3, 2026.
  22. World Anti-Doping Agency. Prohibited List 2026 (in effect January 1, 2026). S0, Non-approved substances. wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf. Read October 3, 2026.

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Checked 23 Oct 2026